grant
Angiotensin-(1-7) and Cardiovascular Derangements in Obesity Hypertension
Organization PENNSYLVANIA STATE UNIV HERSHEY MED CTRLocation HERSHEY, UNITED STATESPosted 15 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AcuteAddressAng I (1-7)AngiotensinsAnimal ModelAnimal Models and Related StudiesAnti-Hypertensive AgentsAnti-Hypertensive DrugsAnti-HypertensivesAreaBP reductionBlood PressureBlood VesselsCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCatecholaminesCausalityChronicClampingsClinicalClinical DataClosure by clampCross-Over StudiesCrossover StudiesDataDevelopmentDiameterDiseaseDisorderDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyEchographyEchotomographyEndocrine Gland SecretionEndogenous Nitrate VasodilatorEndotheliumEndothelium-Derived Nitric OxideEpidemicEtiologyEuglycemic ClampingEuglycemic-hyperinsulinemic ClampGlucose ClampHealthHeart VascularHormonesHumanHumulin RHyperinsulinemic ClampHypertensionHypotensive AgentHypotensive DrugsIndividualInfusionInfusion proceduresInsulinInsulin ResistanceIntravenousKnowledgeLaboratoriesMeasuresMediatingMedical UltrasoundMetabolicMethodsModelingModern ManMononitrogen MonoxideMuscleMuscle TissueNerveNitric OxideNitrogen MonoxideNitrogen ProtoxideNovolin RObese MiceObesityObesity Related HypertensionOrganOutcomePatientsPhysiologicPhysiologicalPlacebo ControlPure Autonomic FailuresRandomizedRegular InsulinRenin-Angiotensin SystemResearchRiskRodent ModelRoleSympathinsTestingTherapeuticTherapeutic HormoneUltrasonic ImagingUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestVascular EndotheliumVascular Hypertensive DiseaseVascular Hypertensive DisorderVasodilatationVasodilationVasorelaxationadiposityangiotensin I (1-7)angiotensin-(1-7)anti-hypertensionblood pressure elevationblood pressure reductionbrachial arterycardiovascular disordercausationcirculatory systemcontrast enhancedcorpulencedevelopmentaldiagnostic ultrasounddisease causationelevated blood pressureendothelial cell derived relaxing factorendothelial dysfunctionglucose RAglucose productionglucose rate of appearanceglucose uptakehigh blood pressurehyperpiesiahyperpiesishypertensivehypertensive diseasehypertensive disorderimprovedincrease in blood pressureincreased blood pressureinfusionsinnovateinnovationinnovativeinsulin resistantinsulin sensitivityinsulin tolerancelower BPlower blood pressurelowers blood pressuremetabolic profilemodel of animalmouse modelmultidisciplinarymurine modelmuscularnovelob/ob mouseobesity interventionobesity therapyobesity treatmentpatient populationpharmacologicplacebo controlledrandomisationrandomizationrandomly assignedrecruitreduce BPreduce blood pressurereduction in BPreduction in blood pressureresponseshear stresssocial rolesonogramsonographysound measurementstable isotopetoolultrasound imagingultrasound scanningvascular
Description preview
PROJECT SUMMARY
Obesity is a global epidemic that is associated with sympathetic overactivation, endothelial dysfunction, and
insulin resistance; all of which can contribute to hypertension development. Despite well-established clinical
associations, the mechanisms connecting obesity with hypertension remain poorly understood, with several…
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