grant
Androgen Receptor Action in Castration Resistant Prostate Cancer
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 24 May 2013Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AgonistAndrogen ReceptorAndrogenic AgentsAndrogenic CompoundsAndrogensApoptosisApoptosis PathwayAutomobile DrivingBRCA1BRCA1 Gene ProductBRCA1 ProteinBRCA1 geneBRCA2BRCA2 geneBenignBiometricsBiometryBiostatisticsBreast Cancer 1 GeneBreast Cancer 1 Gene ProductBreast Cancer 2 GeneBreast Cancer Type 1 Susceptibility GeneBreast Cancer Type 1 Susceptibility ProteinBreast Cancer Type 2 Susceptibility GeneBreast-Ovarian Cancer ProteinBypassCCAAT-Box Binding Transcription FactorCastrate sensitive prostate cancerCell BodyCell Communication and SignalingCell Growth in NumberCell LineCell MultiplicationCell ProliferationCell SignalingCell SurvivalCell ViabilityCell divisionCellLineCellsCellular ProliferationCellular biologyChromatinClinicalCollectionDNA DamageDNA InjuryDependenceDevelopmentDrug resistanceEarly Onset Gene Breast Cancer 1Early Onset Gene Breast Cancer 2Early Onset Protein Breast Cancer 1EffectivenessEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitheliumEquilibriumEventFANCD1FoundationsFundingGene ExpressionGene TranscriptionGeneralized GrowthGenetic TranscriptionGenomicsGoalsGrowthHereditary Breast Cancer 1Hereditary Breast Cancer 2Intracellular Communication and SignalingKnowledgeLengthMalignant neoplasm of prostateMalignant prostatic tumorMediatingNF-I ProteinNFI Transcription FactorNormal CellNuclear Factor IOncogene ActivationOncogenicPARP InhibitorPARP inhibitionPARP-1 inhibitorPARPiPDX modelPathologyPathway interactionsPatient SelectionPatient derived xenograftPatientsPhase 1/2 Clinical TrialPhase I/II Clinical TrialPlayPoly(ADP-ribose) Polymerase InhibitorPoly(ADP-ribose) polymerase 1 inhibitorProgrammed Cell DeathProliferatingProstate CAProstate CancerProstate malignancyProteinsRNA ExpressionRNA SplicingRNF53Receptor ActivationReceptor SignalingRepressionResearch ResourcesResistanceResourcesRoleSamplingSelection for TreatmentsSeriesSignal TransductionSignal Transduction SystemsSignalingSplicingStrains Cell LinesTestingTestosteroneTetTetanus Helper PeptideTherapeuticTherapeutic AndrogenTherapeutic TestosteroneTissue GrowthTrans-TestosteroneTranscriptionTranslatingTumor CellTumor Suppressor ProteinsVCaPVariantVariationWorkXtandiandrogen independent prostate cancerandrogen indifferent prostate cancerandrogen insensitive prostate cancerandrogen resistance in prostate cancerandrogen resistant prostate cancerandrogen sensitive prostate cancerantagonismantagonistbalancebalance functionbiological signal transductionbrca 1 genebrca 2 genecastration resistant CaPcastration resistant PCacastration resistant prostate cancercell biologyclinical developmentclinical relevanceclinically relevantcultured cell linedevelopmentaldrivingdrug resistantenzalutamideepigeneticallyepigenomicshormone refractory prostate cancerhormone sensitive prostate cancerinhibitorneoplastic cellnuclear factor 1ontogenypathwaypatient derived xenograft modelpre-clinical studypreclinical studyprogramsprostate cancer cellprostate cancer resistant to androgenprostate tumor cellreceptor functionresistance mechanismresistance to Drugresistantresistant mechanismresistant to Drugrestorationselection of treatmentsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettherapy selectiontreatment selectiontumortumor suppressor
Description preview
Project Summary
A central hypothesis that drove the studies proposed in the currently funded P01 was that androgen receptor
(AR) remained an important driver in prostate cancer (PC) that becomes resistant to AR targeted therapies, and
that adaptations made by tumor cells as they progress create new dependencies and subsequent vulnerabilities
that…
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