grant
Analytical approaches to fatty acid oxygenases and their lipid mediator products
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 1 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20252-cyclopenten-1-oneAddressAnabolismAnimalsArtificial skinAssayBindingBioassayBiochemicalBiological AssayBurn injuryBurnsCell Communication and SignalingCell SignalingCeramidesCollectionCongenital ichthyosisCutaneous DisorderCyclizationDehydrogenasesDermatosesDiabetic woundDiseaseDisorderEnzyme GeneEnzymesEpidermisEpoxidesEpoxy CompoundsEsterificationEstersEvolutionFatty AcidsFish OilsFreedomFundingGeneticHealthHeme ProteinsHemeproteinsHumanHydrogen OxideInflammationIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceLOXLOX geneLeadLeadershipLibertyLinoleate-Oxygen OxidoreductaseLinoleic AcidsLipidsLipoxidaseLipoxygenaseMetabolic PathwayMiceMice MammalsModern ManMolecular InteractionMurineMusNatureNeonatalNull MouseOxidesOxidoreductaseOxidoreductase GeneOxygenasesPathway interactionsPb elementPeptide/Protein ChemistryPermeabilityProductionProtein ChemistryProteinsProteomicsRecombinantsReductasesResearchResearch ResourcesResolutionResourcesRoleSeafood OilSecureSeriesSightSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSkinSkin DiseasesSkin Diseases and ManifestationsSourceSumSynthesis ChemistrySynthetic ChemistryVisionWateradductallenearmbiological signal transductionbiosynthesisburnedcarotene oxidasecutaneous barriercutaneous diseasecyclopentenonedermal barrierdermal diseasedermal disorderdiabetes ulcerdiabetic skin wounddiabetic ulcerepidermal barrierheavy metal Pbheavy metal leadhemoproteinhigh standardichthyosis congenitalinoleateslipid mediatormembernoveloxidationoxidized lipidpathwayprogramspropadienereconstituted skinresolutionssealskin barrierskin disordersocialsocial rolevisual function
Description preview
Analytical approaches to fatty acid oxygenases and their lipid mediator products
Project Summary/Abstract
This program focuses on technically challenging questions related to lipoxygenases, their associated enzymes
and proteins, and an unprecedented higher-resolution analysis of mechanisms of biosynthesis and fate of the
oxidation products. These…
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