grant
Analysis of Bulk Lipid Transport at Membrane Contact Sites
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 19 Jul 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AD dementiaAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimalsAutoregulationBaker's YeastBindingBiologic ModelsBiologicalBiological FunctionBiological ModelsBiological ProcessBrewer's YeastC-terminalCarbonCell BodyCell FunctionCell Membrane LipidsCell PhysiologyCell ProcessCell SurvivalCell ViabilityCell membraneCellsCellular ExpansionCellular FunctionCellular GrowthCellular PhysiologyCellular ProcessCytoplasmic MembraneDNA mutationDefectDevelopmentDiseaseDisorderDrosophilaDrosophila genusDysfunctionEndoplasmic ReticulumErgastoplasmEukaryotic CellExhibitsExocytosisFaceFatsFatty acid glycerol estersFunctional disorderGeneticGenetic ChangeGenetic defectGenetic mutationGenomeGoalsHomeostasisHydrophobicityInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsIntermediary MetabolismKnock-outKnockoutLabelLipid BindingLipid TraffickingLipidsLocationMaintenanceMembraneMembrane LipidsMetabolic ProcessesMetabolismModel SystemMolecularMolecular InteractionMutationN-terminalNH2-terminalNitrogenO elementO2 elementOrganellesOxygenParalysis AgitansParkinsonParkinson DiseasePhenotypePhosphatidyl InositolPhosphatidylinositolsPhosphoinositidesPhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPhysiopathologyPlasma MembranePlayPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrimary ParkinsonismPrimary Senile Degenerative DementiaPropertyProtein FamilyProtein ModificationProtein TraffickingProteinsPtdInsRegulationRodRoleS cerevisiaeS elementS. cerevisiaeSaccharomyces cerevisiaeShapesSignal PathwaySiteSubcellular ProcessSulfurTestingTimeWorkadapter proteinbiologiccell growthdevelopmentalfacesfacialfat metabolismfruit flygenome mutationhuman diseasein vitro activityinsightlipid boundlipid exchange proteinlipid metabolismlipid transfer proteinlipid transportmacromoleculemembrane biogenesismembrane fluxmembrane structurenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathophysiologyplasmalemmaprimary degenerative dementiaprotein functionprotein transportsenile dementia of the Alzheimer typesocial role
Description preview
ABSTRACT
All eukaryotic cells face the critical problem of regulating the subcellular distribution of lipids. The
lipid composition of organelle membranes is distinct, with each membrane containing a specific
subset of lipids that defines organelle identity and regulates organelle function. These membrane
lipids are also critical for intracellular…
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