grant
Analysis of active genetic elements in germline and somatic cell lineages
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AgricultureAllelesAllelomorphsAreaAutomobile DrivingBackBypassCRISPRCRISPR/Cas systemCell BodyCell LineageCellsChromosomesClustered Regularly Interspaced Short Palindromic RepeatsComplexCulicidaeDNADNA Damage RepairDNA Nicking EnzymeDNA RepairDNA TherapyDNA cassetteDeoxyribonucleic AcidDevelopmentDiseaseDisorderDorsumDrosophilaDrosophila genusElementsEndonuclease IGametesGene AlterationGene MutationGene Transfer ClinicalGene variantGeneHomologGenesGeneticGenetic InterventionGenetic ProcessesGenomicsGerm CellsGerm LinesGerm-Line CellsGuide RNAHeterozygoteHomologHomologous GeneHomologueHumanImageIn SituInsect VectorsInsectaInsecticide ResistanceInsectsInsects InvertebratesIntervening SequencesIntronsInvestigationLaboratoriesLinkMalariaModelingModern ManModificationMosquitoesMutateNickaseOutcomePaludismParasitesPartner in relationshipPlasmodium InfectionsPopulationReproductive CellsResearchSex CellSideSiteSodium ChannelSodium Ion ChannelsSomatic CellSystemTransgenic OrganismsUnscheduled DNA SynthesisVector-borne diseaseVector-borne infectious diseaseVector-transmitted diseaseVector-transmitted infectious diseaseallelic variantcombatdevelopmentaldrivingendonucleaseenhancer cassetteexpression cassettefood securityfruit flyfunctional restorationgRNAgene cassettegene defectgene drive approachgene drive strategygene drive systemgene drive technologygene repair therapygene therapygene-based therapygenetic cassettegenetic elementgenetic therapygenetic variantgenomic therapygenomic variantheterozygosityimagingimprintinitial cellinsecticide resistantinsightintegration cassettemalaria transmissionmatemutant allelenext generationnext-generation gene drivenovelprogramspromoter cassetterepairrepairedreporter cassetteresistance alleleresistance cassetteresistant allelerestore functionrestore functionalityrestore lost functionselectable cassetteselection cassettesexual cellstop cassettetooltranscription cassettetranscriptional cassettetransgene cassettetransgenictransmission blockingvector-borne illnessvectorborne diseasevectorborne illnessvectorborne infectious diseasevoltage
Description preview
Project Summary: Ten years ago, my laboratory and collaborators pioneered the field of "active genetics", in
which CRISPR-based genetic systems bypass the fundamental rules of traditional genetics. Briefly, a transgenic
cassette expresses the Cas9 endonuclease and a guide RNA (gRNA) that directs DNA cleavage precisely at the
site of its genomic…
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