grant
An intravascular Bioartificial Pancreas (iBAP)
Organization SILICON KIDNEY, LLCLocation SAN RAMON, UNITED STATESPosted 23 Sept 2014Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectAllogenicAmericanAnti-Rejection TherapyAreaArteriesBloodBlood PressureBlood Reticuloendothelial SystemBlood flowBrittle Diabetes MellitusCaliforniaCathetersCell BodyCellsCharacteristicsClinicalClinical ResearchClinical StudyConvectionD-GlucoseDevicesDextroseDiffusionDoseDropsEncapsulatedExposure toFamily suidaeFutureGlucoseHealth Care SystemsHousingHumulin RIDDMIND FilingIND applicationIND packageIND submissionIVGTTImmunosuppressive TherapyImplantInjectionsInsulinInsulin-Dependent Diabetes MellitusInvestigational New Drug ApplicationIslands of Langerhans TransplantationIslands of Pancreas TransplantationIslets of Langerhans GraftingIslets of Langerhans TransplantationJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKidneyKidney Urinary SystemKineticsLegal patentMechanicsMembraneNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesNovolin RNutrientO elementO2 elementOrganOutcomeOxygenPancreasPancreas GraftingPancreas TransplantationPancreaticPancreatic Islets TransplantationPatentsPatientsPerformancePermeabilityPersonsPhasePhysiologicPhysiologicalPigsPolymersPreclinical TestingPreparationPrivatizationProductionProductivityQOLQuality of lifeRegular InsulinRiskSBIRSafetySan FranciscoSi elementSiliconSmall Business Innovation ResearchSmall Business Innovation Research GrantSterilizationSudden-Onset Diabetes MellitusSuidaeSwineT1 DMT1 diabetesT1DT1DMTestingTherapeutic immunosuppressionTissue DonorsType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUltrafiltrationUniversitiesValidationVeinsadulthoodarteriovenous graftartificial immunosuppressionautologous islet transplantationbiocompatibilitybiomaterial compatibilityclinical relevanceclinical translationclinically relevantclinically translatablecommercializationcommon treatmentcostdesigndesigningdiffuseddiffusesdiffusingdiffusionsfasting glucosefirst in manfirst-in-humanglycemic controlhemocompatibilityhuman studyimmunosuppression therapyimplantationimprovedinsulin dependent diabetesinsulin dependent type 1insulin secretionintravenous glucose toleranceintravenous glucose tolerance testisletislet auto transplantationislet beta cell transplantationislet cell transplantislet cell transplantationislet transplantationjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesmechanicmechanicalmembrane structuremultidisciplinarynano porenanoporepig modelpiglet modelpolymerpolymericporcineporcine modelpre-clinicalpre-clinical testingpreclinicalpreparationspressureprototyperenalscaffoldscaffoldingsolutesuidswine modeltype 1 diabetictype I diabetestype I diabetictype one diabetesvalidations
Description preview
Project Summary
Approximately 3 million Americans and around 24 million people worldwide are affected by Type 1 Diabetes
(T1D). Exogenous insulin injection, allogeneic whole organ pancreas transplantation, and allogeneic islet
transplantation are the most common treatments for T1D. These treatments can achieve glycemic control for
many patients…
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