grant
An Image-Guided Microrobotic Drug Delivery Method for Preventive Vascular Interventions
Organization MAYO CLINIC ARIZONALocation SCOTTSDALE, UNITED STATESPosted 21 May 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025AV fistulaAccelerationAddressAffectAmericanAnatomic SitesAnatomic structuresAnatomyAngioplastyArteriesArteriovenous AneurysmArteriovenous fistulaBalloon AngioplastyBindingBloodBlood PlateletsBlood Reticuloendothelial SystemBlood VesselsBlood flowBlood monocyteBypassCD68 antigenCathetersCd68Cell BodyCellsCellular injuryChemicalsChemotactic CytokinesChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureCitratesClinicalClottingCoagulationCoagulation ProcessColoring AgentsCommon Rat StrainsComplexCoronary ArteriosclerosisCoronary Artery DiseaseCoronary Artery DisorderCoronary AtherosclerosisDataDevelopmentDevelopment and ResearchDoseDrug DeliveryDrug Delivery SystemsDrug KineticsDrugsDyesESKDESRDEffectivenessElasticityEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEndothelial CellsEndotheliumEventExcipientsFDA approvedFrequenciesGoalsHealth Insurance for Aged and Disabled, Title 18Health Insurance for Disabled Title 18HemodialysesHemodialysisHemolysisHistologicHistologicallyHomologous Chemotactic CytokinesHumanHydrophobicityHyperplasiaHyperplasticImmuneImmunesIn VitroIndocyanine GreenInferior Vena CavaInferior vena cava structureInfiltrationInflammationInflammatoryInjuryIntercrinesInterventionLigandsMacrophageMarrow monocyteMarrow plateletMeasuresMediatingMedicalMedicareMedicationMethodsModelingModern ManMolecular InteractionMonitorMφOperative ProceduresOperative Surgical ProceduresOrganPaintPathological ConstrictionPatientsPercutaneous Transluminal AngioplastyPeripheral arterial diseasePersonsPharmaceutical PreparationsPharmacokineticsPhysiologicPhysiologicalPlasticizersPlateletsPreventative interventionPreventiveProceduresProcessR & DR&DRatRats MammalsRattusRecoveryResearchRiskRobotRoboticsRotationSIS cytokinesSafetyShapesSolubilitySpatial DistributionStenosisSurfaceSurgicalSurgical InterventionsSurgical ProcedureSystemTechnologyTestingThrombocytesThrombosisTimeTitle 18Toxic effectToxicitiesTransluminal AngioplastyTransluminal Arterial DilatationUjoveridinUmbilical veinVeinsVenousWofaverdinatherosclerotic coronary diseaseblood perfusioncell damagecell injurycellular damagechemoattractant cytokinechemokinechronic kidney diseasecoronary arterial diseasecostdamage to cellsdesigndesigningdevelopmentaldisease modeldisorder modeldrug/agenterythrolysisevidence basehealinghealth insurance for disabledimage guidanceimage guidedimprovedinhibitorinjuriesinjury to cellsinjury to the vasculatureinnovateinnovationinnovativeintervention costintervention for preventionintraluminal angioplastymagnetic devicesmagnetic fieldmicrorobotmicroroboticsmonocytemouse modelmurine modelnovelperipheral artery diseasepig modelpiglet modelporcine modelpreventpreventingprevention interventionpreventional intervention strategypreventive interventionprototyperesearch and developmentsafety assessmentside effectsurgeryswine modelsystemic toxicitythrombotic diseasethrombotic disorderultrasoundvascularvascular injurywireless
Description preview
PROJECT SUMMARY/ ABSTRACT
End-stage kidney disease (ESKD) affects over 800,000 Americans and 4 million people worldwide, with 60% of
patients relying on hemodialysis via arteriovenous fistulas (AVF). Despite diligent monitoring, over 30% of AVFs
develop neointimal hyperplasia (IH), leading to venous stenosis (VS) and thrombosis, causing loss of…
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