grant

An Artificial Intelligence Foundation Model for Functional Neuroimaging: Personalized Prediction, Treatment Stratification, and Biotype Discovery in Major Depressive Disorder

Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 15 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AI systemArtificial IntelligenceBrainBrain Nervous SystemCaringCategoriesCell Communication and SignalingCell SignalingChatGPTClinicalClinical DataClinical ResearchClinical StudyClinical TrialsClinical Trials DesignCommunitiesComplexComputational toolkitComputer ReasoningConfidence IntervalsDataData PoolingData SetDiagnosticDimensionsDiseaseDisorderDysfunctionEducational workshopEncephalonEnrollmentEnvironmentFoundationsFreezingFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFundingGPT-2GPT-3GPT-4HeterogeneityHumanIndividualIntracellular Communication and SignalingK23 AwardK23 MechanismK23 ProgramKnowledgeLabelLearningMR ImagingMR TomographyMRIMRIsMachine IntelligenceMachine LearningMagnetic Resonance ImagingMajor Depressive DisorderMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental DepressionMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)MentorshipModelingModern ManNMR ImagingNMR TomographyNatural Language ProcessingNatureNeurobiologyNeurosciencesNuclear Magnetic Resonance ImagingOutcomeOutcome StudyPatientsPatternPerformancePhysiopathologyPrecision therapeuticsPrediction of Response to TherapyPredispositionProcessPsychiatryPublishingR-Series Research ProjectsR01 MechanismR01 ProgramResearchResearch GrantsResearch Project GrantsResearch ProjectsSamplingScanningScientistSelection for TreatmentsSeriesSertralineSeveritiesSignal TransductionSignal Transduction SystemsSignalingSubgroupSusceptibilitySymptomsTechniquesTestingTimeTrainingTreatment outcomeUniversitiesValidationWeightWorkWorkshopZeugmatographyZoloftanalyzing longitudinalanti-depressant agentanti-depressant drugsanti-depressantsanti-depressive agentsbiobankbiological signal transductionbiorepositorybiotypesburden of diseaseburden of illnessclinical depressionclinical relevanceclinically actionableclinically relevantcomputational resourcescomputational toolboxcomputational toolscomputational toolsetcomputer based predictioncomputerized toolscomputing resourcesconditioningconnectomecustomized therapycustomized treatmentdata harmonizationdata to traindataset to traindepressiondesigndesigningdisabilitydisease burdenenrollexperiencefMRIfMRI scanfunctional MRI scanfunctional magnetic resonance imaging scanglobal healthhands on researchharmonized datahemodynamicsimprovedimproved outcomeindividualized medicineindividualized patient treatmentindividualized predictionsindividualized therapeutic strategyindividualized therapyindividualized treatmentinnovateinnovationinnovativeinsightintervention armlongitudinal analysismachine based learningmajor depressionmajor depression disordernatural language understandingneuralneural circuitneural circuitryneural imagingneural patterningneuro-imagingneurobiologicalneurocircuitryneuroimagingneurological imagingnovelopen labelopen label studyoptimal therapiesoptimal treatmentspathophysiologypatient oriented researchpatient oriented studypatient specific therapiespatient specific treatmentpatient stratificationpersonalization of treatmentpersonalized medicinepersonalized predictionspersonalized therapypersonalized treatmentpilot trialpre-trained modelpre-trained transformerprecision therapiesprecision treatmentpredict responsivenesspredict therapeutic responsepredict therapy responsepredicting responsepredictive modelingpredictive toolsprognosticationprogramsprospectiveprototyperesponseresponse to therapyresponse to treatmentselection of treatmentskillssocietal costsspatial and temporalspatial temporalspatiotemporalstratified patientsuccesssynaptic circuitsynaptic circuitrytailored medical treatmenttailored therapytailored treatmenttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapeutic stratificationtherapy predictiontherapy responsetherapy selectiontooltraining datatraining datasetstransformer architecturetransformer based modeltransformer modeltreatment armtreatment predictiontreatment responsetreatment response predictiontreatment responsivenesstreatment selectiontreatment stratificationunique treatmentvalidationsweights
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PROJECT SUMMARY
Major depressive disorder (MDD) is a leading cause of disability, with substantial individual and societal costs.

The heterogeneity of MDD and the lack of predictive tools for individualized treatment present significant

challenges to effective care. This proposal aims to leverage recent advances in foundation models, a type of…

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An Artificial Intelligence Foundation Model for Functional Neuroimaging: Personalized Prediction, Treatment Stratificati | Dev Procure