grant
ALZHEIMERS RESEARCH PROJECT: DNA repair dysfunction in neurodegeneration and Alzheimer's Disease
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AD dementiaAcuteAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaC elegansC. elegansC.elegansCaenorhabditis elegansCellular AssayCellular StressCellular Stress ResponseChronicDNADNA DamageDNA Damage RepairDNA InjuryDNA RepairDNA Repair DeficiencyDNA Repair DisorderDegenerative Neurologic DisordersDeoxyribonucleic AcidDiseaseDisorderDysfunctionFunctional disorderGoalsHumanMitochondriaModern ManNematodaNematodesNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationPhysiopathologyPlayPrimary Senile Degenerative DementiaR-Series Research ProjectsR01 MechanismR01 ProgramResearch GrantsResearch Project GrantsResearch ProjectsRoleSystemUnscheduled DNA SynthesisWorkage associated diseaseage associated disorderage associated impairmentage associated neurodegenerationage associated neurodegenerative diseaseage associated neurodegenerative disorderage dependent diseaseage dependent disorderage dependent impairmentage dependent neurodegenerationage dependent neurodegenerative conditionage dependent neurodegenerative diseaseage dependent neurodegenerative disorderage related human diseaseage related neurodegenerationage-driven neurodegenerative disordersage-related diseaseage-related disorderage-related impairmentage-related neurodegenerative diseaseage-related neurodegenerative disorderaging associated neurodegenerationaging associated neurodegenerative diseaseaging related neurodegenerationaging related neurodegenerative diseaseaging related neurodegenerative disordercell assaycell stressdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesmitochondrialmouse modelmurine modelneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronal degenerationnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoxidative DNA damagepathophysiologyprimary degenerative dementiaresponseroundwormsenile dementia of the Alzheimer typesocial roletheories
Description preview
Our goal here is to determine whether changes in the formation or processing of oxidative DNA damage are associated with aging and neurodegenerative diseases (AD, PD). It is our hypothesis that DNA repair systems play critical roles in responding to multiple types of acute and chronic cellular stress. We have identified a DNA damage response…
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