grant
ALZHEIMERS RESEARCH PROJECT: Cerebral Microstructure in Aging and Dementia using Advanced Quantitative MRI
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AD dementiaAccelerationAffectAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmentiaAmyloidAmyloid (Aβ) plaquesAmyloid PlaquesAmyloid SubstanceArteriosclerotic DementiaAttorneysAxonBiological MarkersBrainBrain Nervous SystemCerebrumCholesterolCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollaborationsComplexDataDementiaDemocracyDemyelinationsDisturbance in cognitionDysfunctionEarly DiagnosisEncephalonEnsureFe elementFunctional disorderFunctional impairmentFundingGermanyGoalsHealthHydrogen OxideHypertensionImageImpaired cognitionImpairmentIntellectual PropertyInterventionIronLawyersLegal patentLinkLongitudinal StudiesMR ImagingMR TomographyMRIMRIsMT-bound tauMagnetic Resonance ImagingMapsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsModelingMonitorMotorMyelinMyelin ProteinsNMR ImagingNMR TomographyNational Institutes of HealthNerve DegenerationNeuritic PlaquesNeuron DegenerationNuclear Magnetic Resonance ImagingObesityOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellPETPET ScanPET imagingPETSCANPETTPatentsPatternPhysiopathologyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPreventionPrimary Senile Degenerative DementiaPropertyProperty RightsProtocolProtocols documentationR-Series Research ProjectsR01 MechanismR01 ProgramRad.-PETResearchResearch GrantsResearch Project GrantsResearch ProjectsRisk FactorsRoleSecureSenile PlaquesSisterStructureTechniquesUnited States National Institutes of HealthVascular DementiaVascular Hypertensive DiseaseVascular Hypertensive DisorderWaterWorkZeugmatographyadiposityage associated diseaseage associated disorderage associated impairmentage dependent diseaseage dependent disorderage dependent impairmentage related human diseaseage-related diseaseage-related disorderage-related impairmentaging associatedaging relatedamyloid beta plaqueamyloid-b plaqueautosomal dominant ADautosomal dominant Alzheimer's diseaseaxonal degenerationaβ plaquesbio-markersbiobankbiologic markerbiomarkerbiorepositorycardiovascular fitnesscerebralcerebrovascular contributions to dementiacognitive dysfunctioncognitive losscohortcored plaquecorpulencedecline in functiondecline in functional statusdegenerative axondemyelinatedensitydiffuse plaqueearly detectionfunctional declinefunctional status declinehigh blood pressurehyperpiesiahyperpiesishypertensive diseasehypertensive disorderimagingimaging biomarkerimaging markerimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedinsightlong-term studylongitudinal outcome studiesmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentmyelinationnatural agingneural degenerationneural imagingneural inflammationneuro-imagingneurodegenerationneurodegenerativeneuroimagingneuroinflammationneuroinflammatoryneurological degenerationneurological imagingneuronal degenerationnormal agingnormative agingpathophysiologypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyprimary degenerative dementiaprogramssenile dementia of the Alzheimer typesocial rolesubstantia albatautau Proteinstau factortheoriesvascular contributions in dementiavascular contributions to dementiavascular related dementiawhite matterwhite matter changeτ Proteins
Description preview
The dominant theory of Alzheimer's disease (AD) focuses on amyloid-beta plaques and tau proteins causing cognitive impairment. However, this theory has been questioned due to failed treatments targeting amyloid. Recent research highlights significant changes in white matter (WM) microstructure and composition in AD, including decreased myelin…
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