grant
ALZHEIMERS RESEARCH PROJECT: B cells promote Alzheimers disease via cytolytic CD8+ T cells
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AD dementiaAD pathologyAblationAffectAgeAgingAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer like pathologyAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's brainAlzheimer's disease brainAlzheimer's disease like pathologyAlzheimer's disease pathologyAlzheimer's pathologyAlzheimers DementiaAmentiaAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAntibodiesAntigensAβB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBONZOBindingBody TissuesBrainBrain Nervous SystemCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCXCR6CXCR6 geneCell BodyCellsCirculationCo-cultureCocultivationCocultureCoculture TechniquesComplexDementiaDepositDepositionDiseaseDisease associated microgliaDisorderEOADEarly Onset Alzheimer DiseaseEctopic lymphoid organEctopic lymphoid structureEncephalonEventGenerationsGeneticHortega cellHumanImmunizationImpairmentInfiltrationLinkMediatingMemoryMeningesMiceMice MammalsMicrogliaModern ManMolecular InteractionMurineMusNatureNerve DegenerationNeuron DegenerationNeuronal DysfunctionPathogenicityPathologicPeptidesPeripheralPhagocytosisPhenotypePlayPrimary Senile Degenerative DementiaProbabilityPublishingR-Series Research ProjectsR01 MechanismR01 ProgramRNA vaccineRNA-based vaccineReportingResearch GrantsResearch Project GrantsResearch ProjectsRoleSTRL33SynapsesSynapticT cell infiltrationT8 CellsT8 LymphocytesTYMSTRTauopathiesTertiary lymphoid structureTestingTissuesTransgenic MiceWorka beta peptideabetaadaptive immunityagedaged miceaged mouseagesamyloid betaamyloid-b proteinastrogliosisbeta amyloid fibrilbrain parenchymaearly onset ADearly onset Alzheimer'selderly miceexhaustexhaustionexperimentexperimental researchexperimental studyexperimentsgitter cellimmunogenmRNA vaccinemRNA-based vaccinemeningemesogliamicroglial cellmicrogliocyteneural degenerationneural dysfunctionneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationneuropathologic tauneuropathological tauneurotoxicold miceperivascular glial cellprimary degenerative dementiarecruitsenile dementia of the Alzheimer typesexsocial rolesoluble amyloid precursor proteinsynapsetau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytertiary lymphoid organ
Description preview
According to the prevailing Amyloid cascade hypothesis, Alzheimers disease (AD) is caused by decades-long deposition of neurotoxic amyloid Ab-peptide aggregates (Ab plaques) in the brain. It leads to a chain of pathological events, including tauopathy, astrogliosis, accumulation of disease associated microglia (DAM), synaptic and neuronal…
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