grant
Alzheimer's Disease and Related Dementia Neuropathologies and Exposures to Traffic Pollution Mixtures
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 1 Jun 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAD dementiaAD related dementiaADRDAPOEASCVDAddressAdsorptionAdultAdult HumanAir PollutionAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAnimalsApo-EApoE proteinApolipoprotein EAreaArteriolosclerosesAtherosclerosisAtherosclerotic Cardiovascular DiseaseAttentionAttenuatedAutopsyBiologic FactorBiological FactorsBrainBrain Nervous SystemCarbon BlackCerebrumChildChild YouthChildren (0-21)ClinicalClinical DataCognitiveCommunitiesComplex MixturesDataDevelopmentDiameterDietDropsEconomicsEncephalonEnvironmental ExposureEpidemiologic MethodologyEpidemiologic MethodsEpidemiologic research methodologyEpidemiologic research methodsEpidemiological MethodsEpidemiological TechniquesEpidemiologyEvidence based interventionExerciseExposure toFundingFutureGasesGoalsHealthHistoryIndividualInfarctionInflammationInternationalInterventionInvestigationLeadLearningLinkMeasurementMeasuresMedicalMentorshipMethodsMethods EpidemiologyMethods in epidemiologyModelingMonitorNeurofibrillary TanglesNitrogen OxidesOutcomeOxidative StressPM0.1PM2.5ParticipantPathologyPb elementPoisonPollutionPopulationPositionPositioning AttributePredispositionPrimary Senile Degenerative DementiaPrincipal InvestigatorQualifyingRecording of previous eventsRegistriesRegulationReportingResearchRisk FactorsSamplingScienceSurfaceSusceptibilityTechniquesTimeToxic ChemicalToxic SubstanceToxic effectToxicitiesToxicologyTrainingUltrafine ParticulatesWomanabeta depositionadult youthadulthoodaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging populationamyloid beta depositionamyloid β depositionatheromatosisatherosclerotic diseaseatherosclerotic vascular diseaseattenuateattenuatesaβ depositionbrain vascular pathologybrain vascular pathophysiologycareercerebralcerebral angiopathycerebral vascular pathologycerebral vasculopathycerebrovascular abnormalitycerebrovascular defectcerebrovascular disease pathologycerebrovascular pathologycerebrovascular pathophysiologycerebrovasculopathycohortdeath riskdemographicsdesigndesigningdevelopmentaldietseconomicepidemiologicepidemiologicalexperiencefine particlesfine particulate matterheavy metal Pbheavy metal leadhistorieshyper-phosphorylated tauhyperphosphorylated tauimprovedinfarctinnovateinnovationinnovativeinsightinterestkidslate in lifelate lifelife-style factorlifestyle factorslow SESlow socio-economic positionlow socio-economic statuslow socioeconomic positionlow socioeconomic statusmalleable riskmodifiable riskmortality risknecropsyneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneuron toxicityneuronal toxicityneuropathologicneuropathologicalneuropathologyneurotoxicneurotoxicitynovelolder adultolder adulthoodolfactory bulbparticleparticle counterparticle exposureparticle monitorpollutantpopulation agingpostmortemprimary degenerative dementiasenile dementia of the Alzheimer typeskillssocialtangletoxic compoundtraffic-related air pollutionultrafine particleultrafine particulate matteryoung adultyoung adult ageyoung adulthoodyounger ageyoungster
Description preview
PROJECT SUMMARY
Alzheimer’s Disease (AD) and Related Dementias (ADRD) are a growing concern in our aging population. The
identification of modifiable risk factors is critical. Growing evidence links ADRD to traffic-related air pollution
(TRAP), a complex mixture of gasses and particles that includes ultrafine particles (UFP, ≤ 100 nm diameter),…
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