grant
Alzheimer's Clinical Trials Consortium (ACTC)
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 2 Dec 2017Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AD dementiaAD pathologyAD related dementiaADRDAbscissionAccelerationAccountabilityActive Follow-upAddressAgreementAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease biological markerAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related dementiaAlzheimer's pathologyAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmericanAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAutopsyAβBenchmarkingBest Practice AnalysisBiological MarkersBiometricsBiometryBiostatisticsBloodBlood PlasmaBlood Reticuloendothelial SystemBrainBrain Nervous SystemCell Communication and SignalingCell SignalingClinicClinicalClinical InvestigatorClinical ResearchClinical StudyClinical TrialsCognitiveCollaborationsCommunitiesComputer softwareConsensusContracting OpportunitiesContractsCooperative AgreementsCountryDataData AnalysesData AnalysisData SystemsDecision MakingDegenerative Neurologic DisordersDevelopmentDiseaseDisorderDrugsEducationEducational aspectsEncephalonEnrollmentExcisionExpenditureExtirpationFosteringFundingFutureGoalsIRBIRBsIT SystemsImageImmunoassayImprove AccessInformaticsInformation SystemsInformation Technology SystemsInfrastructureInstitutionInstitutional Review BoardsInterventionIntervention TrialInterventional trialIntracellular Communication and SignalingInvestigatorsLeadershipLearningMR ImagingMR TomographyMRIMRIsMT-bound tauMagnetic Resonance ImagingMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMentorsMentorshipMethodsMissionModelingMulti-center trialMulticenter TrialsNMR ImagingNMR TomographyNational Institutes of HealthNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNuclear Magnetic Resonance ImagingOutcomeOutcome MeasurePETPET ScanPET imagingPETSCANPETTParticipantPerformancePharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhasePlasmaPlasma SerumPopulationPopulation HeterogeneityPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary PreventionPrimary Senile Degenerative DementiaPrivatizationProceduresProcessProtocolProtocols documentationRad.-PETRegistriesRemovalResearchResearch DesignResearch PersonnelResearch ResourcesResearch SpecimenResearchersResourcesReticuloendothelial System, Serum, PlasmaSafetySamplingScreening procedureSignal TransductionSignal Transduction SystemsSignalingSiteSlideSoftwareSpecimenStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStructureStudy TypeSurgical RemovalTherapeuticTherapeutic TrialsTissue BanksTissue CollectionTissue repositoryTrainingTrustU-Series Cooperative AgreementsUnderrepresented GroupsUnderrepresented PopulationsUnited States National Institutes of HealthWorkZeugmatographya beta peptideabetaactive followupamyloid betaamyloid-b proteinasymptomatic Alzheimer'sasymptomatic Alzheimer's diseasebenchmarkbeta amyloid fibrilbio-markersbiobankbiologic markerbiological signal transductionbiomarkerbiorepositoryclinical trial participantclinical trial recruitmentcognitive assessmentcognitive testingcomputerizeddata interpretationdata managementdata sharingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmentaldigitaldiverse populationsdrug developmentdrug/agentefficacious therapyefficacious treatmentelectronic data capture systemenrollevidence baseexperiencefollow upfollow-upfollowed upfollowupheterogeneous populationimagingimprovedinnovateinnovationinnovativeinstrumentmeasurable outcomemicrotubule bound taumicrotubule-bound taunecropsyneural imagingneuro-imagingneurodegenerative dementianeurodegenerative illnessneuroimagingneurological imagingneuropathologicneuropathologicalneuropathologynew approachesnext generationnovelnovel approachesnovel strategiesnovel strategyopen dataopen scienceopen-source dataoperationoperationsoutcome measurementp-taup-τpharmaceuticalphospho-tauphospho-τphosphorylated taupopulation diversitypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypost-translational modification of taupostmortemposttranslational modification of taupragmatic effectiveness trialpragmatic trialpre-clinicalpreclinicalprimary degenerative dementiaprogramspublic-private partnershiprecruitresectionscreeningscreening toolsscreeningssenile dementia of the Alzheimer typesmall moleculesoluble amyloid precursor proteinstatistical analysisstudy designsuccesstautau Proteinstau factortau phosphorylationtau posttranslational modificationtau-1trial designtrial enrollmentunder representation of groupsunder represented groupsunder represented peopleunder represented populationsunderrepresentation of groupsunderrepresented peopleuser-friendlyτ Proteinsτ phosphorylation
Description preview
This is a multi-PI application renewing the U24 Cooperative Agreement to sustain and expand the NIA’s state-of-the-art Alzheimer Clinical Trial Consortium (ACTC) responsible for conducting academic clinical trials across the continuum of Alzheimer’s disease (AD). This ACTC will continue to leverage the depth and breadth of AD clinical research…
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