grant
Alternative Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202521+ years old4-(methylnitrosamino)-1-(3-pyridyl)-1-butanolActive Follow-upAdultAdult HumanAffectAlternative Nicotine Delivery SystemsBehaviorBehavioralBiochemicalBiological MarkersCarbon MonoxideCarcinogen exposureCessation of lifeChemicalsCigaretteCigarette SmokerCollectionDataDeathDrugsElectronic Nicotine Delivery ProductElectronic Nicotine Delivery SystemsElectronic cigaretteFosteringHarm MinimizationHarm ReductionHealthIndustryInhalationInhalingInvestigationLaboratoriesMeasuresMedicationMorbidityMorbidity - disease rateNNALNicotineNitrosaminesOralOutcome MeasureParticipantPharmaceutical PreparationsPhaseProtocolProtocols documentationPsychological reinforcementRandomizedRegimenReinforcementReportingResearchRewardsRouteSmokerSmokingSpirometrySurgeonSymptomsTobaccoToxicant exposureVisitWithdrawalactive followupadulthoodalternative tobaccobio-markersbiologic markerbiomarkercease smokingcigarette smokecigarette smokingcigarette usecombustible cigaretteconventional cigarettecravingdrug/agente-cige-cig usee-cigarettee-cigarette useecigecig useecigaretteecigarette useelectronic cigarette useelectronic nicotine delivery deviceelectronic nicotine distribution systemfollow upfollow-upfollowed upfollowupimprovedinterestlung functionmeasurable outcomemortalitynegative affectnegative affectivitynon-cigarette productsnon-cigarette tobacco productnoveloutcome measurementprimary outcomeprolonged abstinenceprospectivepulmonary functionquit smokingrandomisationrandomizationrandomly assignedsecondary end pointsecondary endpointsecondary outcomesmoking abstinencesmoking cessationsmoking exposurestop smokingsuccesssustained abstinencetooltoxic exposuretraditional cigarette
Description preview
PROJECT SUMMARY
Nearly 70% of the ~ 30 million adult cigarette smokers in the US want to quit, and 55% report trying to quit at
least once in the past year - yet, over 90% fail despite using smoking cessation medication. The average smoker
will attempt to quit smoking at least 30 times before abstaining for 12 months or longer. These attempts…
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