grant
Altered High-Density Lipoprotein function in Patients with Idiopathic Inflammatory Myopathies
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025ADP Phosphocreatine PhosphotransferaseASCVDATP Creatine PhosphotransferaseAccelerationActive Follow-upAddressAffectAnti-InflammatoriesAnti-Inflammatory AgentsAnti-Rejection TherapyAnti-inflammatoryAntibodiesAntioxidantsApo A-1Apo A-IApo A1Apo AIApoA-1ApoA-IApolipoprotein A-1Apolipoprotein A-IApolipoprotein A1Apolipoprotein AIAreaArylesteraseAtherosclerosisAtherosclerotic Cardiovascular DiseaseAtrophic ArthritisAutoimmune DiseasesBlood VesselsCaliforniaCardiopulmonaryCardiovascular DiseasesCellular injuryCholesterolClinicalComplexComplicationCore FacilityCreatine KinaseCreatine Kinase-BCreatine Kinase-B ChainCreatine PhosphokinaseDataData CollectionDermatomyositisDermatopolymyositisDietary InterventionDiseaseDisease OutcomeDisorderEndothelial CellsEndotheliumEnzyme GeneEnzymesFatty Acid HydroperoxidesFoundationsGI microbiomeGeneral TaxonomyGoalsHDLHDL LipoproteinsHeavy LipoproteinsHemi-MyeloperoxidaseHigh Density LipoproteinsIdiopathic Inflammatory MyopathiesImmunosuppressive TherapyImpairmentInflammatoryInstitutionInterstitial Lung DiseasesKnowledgeLDLLDL LipoproteinsLaboratoriesLinkLipid HydroperoxideLipid PeroxidesLipidsLipoperoxidesLong-term cohortLongitudinal cohortLos AngelesLow-Density LipoproteinsLupus Erythematosus DisseminatusMeasuresMediatingMediatorMentorsMethodsMicrobiomicsModificationMyeloperoxidaseNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic InfiltrateNutrition InterventionsNutritional InterventionsOrganOutcome MeasureOxidative StressPON1Paraoxonase 1PathogenesisPatientsPeroxidasesPhosphatidesPhospholipidsPhysiciansPolymyositis-DermatomyositisProbioticsProcessProgressive DiseasePropertyProteinsResearchResearch DesignResearch ResourcesResourcesRheumatoid ArthritisSLEScientistSeveritiesStandardizationStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStudy TypeSubgroupSystemSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusTaxonomyTechniquesTestingTherapeutic immunosuppressionTimeTrainingUniversitiesVascular DiseasesVascular DisorderVascular EndotheliumWorkactive followupalpha-Lipoproteinsanti-oxidant enzymeantioxidant enzymeartificial immunosuppressionatheromatosisatherosclerotic diseaseatherosclerotic vascular diseaseautoimmune conditionautoimmune disorderautoimmunity diseasebeta-Lipoproteinsbiomarker arraybiomarker panelblood vessel disorderburden of diseaseburden of illnesscardiovascular disordercardiovascular healthcareer developmentcell damagecell injurycellular damagechest CTchest computed tomographycirculating biomarkerscirculating markerscohortdamage to cellsdiet interventiondigestive tract microbiomedisease burdendisease controldisorder controldisseminated lupus erythematosusendothelial dysfunctionenteric microbiomefecal microbial transplantationfecal microbiomefecal microbiome transplantationfecal microbiota transplantfecal microbiota transplantationfecal samplefecal transplantfecal transplantationfollow upfollow-upfollowed upfollowupgastrointestinal microbiomegut microbiomegut-associated microbiomeimmunosuppression therapyimpaired pulmonary vascularizationimprovedinjury to cellsinjury to the vasculatureintestinal biomeintestinal microbiomelipid mediatorlipid peroxidelung healthlung vascular diseasemarker panelmeasurable outcomemicrobialmicrobial compositionmicrobial consortiamicrobial floramicrobiomemicrobiome researchmicrobiome sciencemicrobiome studiesmicrobiotamicrofloramortalitymouse modelmultidisciplinarymultispecies consortiamurine modelnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetoutcome measurementoxidationparticlepeptide mimeticpeptide mimicpeptidomimeticspreventpreventingpulmonary healthpulmonary vascular diseasepulmonary vascular disorderpulmonary vascular dysfunctionpulmonary vascular permeabilitypulmonary vasculopathyquantitative imagingrheumatic arthritisstatistical analysisstool microbiomestool samplestool specimenstool-associated microbiomestudy designsystemic lupus erythematosistherapeutic candidatetherapeutic targetultrasoundvascularvascular dysfunctionvascular injuryvasculopathy
Description preview
PROJECT SUMMARY/ABSTRACT
Damage to the vascular endothelium is responsible for cardiovascular disease, which is the leading cause of
mortality in patients with autoimmune diseases. In idiopathic inflammatory myopathies (IIM), this process is
particularly relevant as vascular damage is implicated in the disease pathogenesis as well as its…
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