grant
Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study
Organization DIVISION OF CANCER EPIDEMIOLOGY AND GENETICSLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Active Follow-upAgeAll-Trans-RetinolAnti-Infective vitaminAntioxidantsAntixerophthalmic vitaminAreaAxerophtholAxerophtholumBiochemicalBiologicalBiological MarkersBiosterolBladderBladder CancerBladder Urinary SystemBlood SerumBlood erythrocyteBreast CancerBronchiCXRCancer CauseCancer EtiologyCancer InterventionCancersCapsulesCarbonCarotenes and CarotenoidsCarotenoidsCategoriesCaucasianCaucasian RaceCaucasiansCaucasoidCaucasoid RaceCessation of lifeChestCigaretteCohort AnalysesCohort AnalysisCollaborationsColonColon or RectumColorectalColorectal CancerDataDeathDiagnosisDietDietary QuestionnairesDimensionsDiseaseDisorderEXTMREpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchErythrocytesErythrocyticEvaluationExtramuralExtramural ActivitiesFilmFinlandFolateFolic AcidFollow-Up StudiesFollowup StudiesFoodFreezingGWA studyGWASGastric Body CancerGastric CancerGastric Cardia CancerGastric Fundus CancerGastric Pylorus CancerGene variantGeneticGenetic PolymorphismGenome ScanGenotypeGlial Cell TumorsGlial NeoplasmGlial TumorGliomaGoalsGonadal Steroid HormonesGrowth AgentsGrowth FactorGrowth SubstancesHDL CholesterolHDL Cholesterol LipoproteinsHabitsHead and NeckHead and neck structureHealthHigh Density Lipoprotein CholesterolHumanHuman ResourcesHumulin RInsulinIntermediary MetabolismInternationalInterventionInvestigationInvestigatorsKidney CancerKidney CarcinomaLard-FactorLungLung Respiratory SystemMalignant Bladder NeoplasmMalignant Breast NeoplasmMalignant Gastric NeoplasmMalignant Gastric TumorMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant Tumor of the BladderMalignant Tumor of the LungMalignant neoplasm of lungMalignant neoplasm of pancreasMalignant neoplasm of prostateMalignant neoplasm of urinary bladderMalignant prostatic tumorManpowerMarrow erythrocyteMeasurementMedicalMedical RecordsMetabolicMetabolic ProcessesMetabolismModern ManMolecularNCI OrganizationNational Cancer InstituteNested Case-Control StudyNeuroglial NeoplasmNeuroglial TumorNovolin RNutrientNutritionNutritionalOccidentalOccupationalOleovitamin AOphthalaminP50 MechanismP50 ProgramPLRAPancreasPancreas CancerPancreaticPancreatic CancerParticipantPathologyPhasePhenotypePlacebosPleuraPleural TissuePopulation RegistersProceduresProductivityProspective StudiesProstateProstate CAProstate CancerProstate GlandProstate malignancyProstatic GlandProteins Growth FactorsPteroylglutamic AcidPublic HealthPulmonary CancerPulmonary malignant NeoplasmR-Series Research ProjectsR01 MechanismR01 ProgramRandomizedRandomized, Controlled TrialsRectumRed Blood CellsRed CellRegular InsulinRenal CancerRenal CarcinomaResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ResourcesResearch SpecimenResearchersResourcesSamplingSe elementSeleniumSerumSex HormonesSex Steroid HormonesSham TreatmentSlideSmokerSmokingSolateneSpecialized CenterSpecimenStomach CancerStructure of nail of toeSupplementationSurvey InstrumentSurveysTestingThoraceThoracicThoracic RadiographyThoraxTocopherol acetateToe NailToenailTracheaTrachea ProperUrinary Bladder CancerUrinary Bladder Malignant TumorVIT DVisitVitamin A AlcoholVitamin DVitamin EVitamin E AcetateVitamin MVitaminsWhole Bloodactive followupagesallelic variantalpha-Lipoprotein Cholesterolalpha-tocopherol acetatealpha-tocopheryl acetateattributable riskbeta,beta-Carotenebio-markersbiologicbiologic markerbiomarkerblood corpusclescancer epidemiologycancer preventioncancer registrycapsulecarotenoid biosynthesiscase controlcase-controlledchest X raychest Xraychest radiographycohortcolorectumd-alpha-Tocopherol acetated-alpha-tocopheryl acetatedesigndesigningdiet and cancerdietarydietseffectiveness testingenergy balanceepidemiologic investigationepidemiology studyfollow upfollow-upfollowed upfollowupgastric malignancygenetic analysisgenetic variantgenome wide associationgenome wide association scangenome wide association studygenome-wide scangenomewide association scangenomewide association studygenomewide scangenomic variantglial-derived tumorgonadal steroidsgroup interventioninterestintervention effectlung cancerlung radiographymalemalignancymalignant breast tumormalignant stomach neoplasmmalignant stomach tumormenmetabolism measurementmetabolomicsmetabonomicsneoplasm registryneoplasm/cancerneuroglia neoplasmneuroglia tumornutritiouspancreatic malignancypersonnelpolymorphismpopulation basedpost interventionpreventpreventingprostate cancer riskradiographic chest imageradiographic lung imagerandomisationrandomizationrandomized control trialrandomly assignedrecruitretinolsex steroidsham therapyside effectstomach fundus cancerstomach pylorus cancerthoracic radiogramthorax radiographytocopherolacetate-d-alphatocopheryl acetateurinary bladdervitamin Bcweb sitewebsitewhite racewhole genome association analysiswhole genome association studywhole-genome scanwindpipeα-Tocopherolβ-Carotene♂
Description preview
The ATBC Cohort Follow-up Study has been in place since 1994. Male smokers between the ages of 50 and 69 were recruited from southwestern Finland between April 1985 and June 1988. A total of 29,133 men were randomly assigned to one of four intervention groups: 50 mg/day alpha-tocopherol (as dl-alpha-tocopheryl acetate); 20 mg/day beta-carotene;…
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