grant
Alpha- to Beta-Cell Communication in Health and Disease
NIHUS FederalResearch GrantFY2025Adult-Onset Diabetes MellitusAgeAlpha CellAntidiabetic HormoneArginineAutomobile DrivingAutoregulationBeta CellBlood GlucoseBlood PlasmaBlood SugarCell CommunicationCell FunctionCell InteractionCell PhysiologyCell ProcessCell-to-Cell InteractionCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCirculationClinical ResearchClinical StudyCompensationComplexCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyD-GlucoseDataDependenceDextroseDiabetes MellitusDiseaseDisease Frequency SurveysDisorderDrug ControlsDysfunctionEndocrine Gland SecretionEndopeptidase PC2EquilibriumFailureFastingFunctional disorderGLP-1GLP-1 receptorGLP-I receptorGenderGlp-1GlucagonGlucagon CellGlucagon ReceptorGlucagon Secreting CellGlucoseGlukagonHG-FactorHealthHepaticHomeostasisHormonesHumanHumulin RHyperglycemiaHyperglycemic-Glycogenolytic FactorHypoglycemiaImpairmentIndividualInfusionInfusion proceduresInsulinInsulin CellInsulin ResistanceInsulin Secreting CellIntakeIntermediary MetabolismInterruptionIntravenousInvestigatorsKetosis-Resistant Diabetes MellitusL-ArginineLeannessLiteratureLiverMaturity-Onset Diabetes MellitusMeasuresMediatingMetabolicMetabolic ProcessesMetabolic stressMetabolismMiceMice MammalsModern ManMurineMusNIDDMNeuroendocrine Convertase PC1Neuroendocrine Convertase PC2Non-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNutrientObesityOver weightOverweightPC1PC1 EndoproteasePC1 Prohormone ConvertasePC2PC2 EndoproteasePC2 Prohormone ConvertasePC2 ProteinPC3 EndoproteasePC3 Prohormone ConvertasePathogenesisPeptide Signal SequencesPeptidesPeripheralPersonsPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlasmaPlasma SerumProcessProductionProhormone Convertase 1Prohormone Convertase 2Prohormone Convertase 3Proinsulin Convertase 1Proinsulin Convertase 2Proprotein Convertase 1Proprotein Convertase 2Proprotein Convertase SPC3PublishingReceptor SignalingRegular InsulinRegulationResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRoleSignal PeptideSignal SequencesSlow-Onset Diabetes MellitusStable Diabetes MellitusStimulusSubcellular ProcessT2 DMT2DT2DMTestingTherapeutic HormoneThinnessType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWeightWorkadiposityadult onset diabetesagesalpha-cellantagonismantagonistbalancebalance functionblood glucose regulationcell stresscorpulencediabetesdiabetes pathogenesisdiabeticdiet-associated obesitydiet-induced obesitydiet-related obesitydrivingfastedfastsglucagon-like peptide 1glucagon-like peptide-1 receptorglucose RAglucose controlglucose homeostasisglucose productionglucose rate of appearanceglucose regulationglucose toleranceglycemic controlhepatic body systemhepatic organ systemhuman subjecthyperglycemichypoglycemichypoglycemic episodesin vivoinfusionsinsulin resistantinsulin secretioninsulin sensitivityinsulin toleranceinterestisletketosis resistant diabetesknock-downknockdownmaturity onset diabetesmouse modelmurine modelneuralnon-diabeticnondiabeticobese individualsobese peopleobese personobese populationobese subjectsparacrinepathophysiologypre-clinical studypreclinical studypreventpreventingpro-glucagonproglucagonprotein signal sequenceresponsesocial roletranslational studytype 2 DMtype II DMtype two diabetesweightsα-cellβ-cellβ-cellsβCell
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Summary of Work
Glucagon is canonically viewed as an essential counterregulatory hormone that prevents hypoglycemia by driving
endogenous glucose production (EGP) in the liver. We and others have revealed additional roles for glucagon
that emphasize a much more complex control of metabolism beyond hypoglycemia. On such role is our studies…
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