grant
ALDH1A1-Negative Nigrostriatal Dopaminergic Neuron Subtypes in Parkinsons Disease
Organization NATIONAL INSTITUTE ON AGINGLocation UNITED STATES
NIHUS FederalResearch GrantFY2025ALDHAffectBasal GangliaBasal NucleiBehaviorCell BodyCellsCognitiveComplexDA NeuronDREADDsDecision MakingDopamineDopamine neuronDorsalECB signalingGene ExpressionGeneticGoalsHumanHydroxytyramineIndividualKI miceKnock-in MouseLocomotionMesencephalonMiceMice MammalsMid-brainMidbrainMidbrain structureModern ManMolecularMotivationMotorMovementMurineMusNerve CellsNerve DegenerationNerve UnitNeural CellNeurocyteNeuron DegenerationNeuronsParalysis AgitansParkinsonParkinson DiseasePathologicPathway interactionsPrimary ParkinsonismPrimatesPrimates MammalsReaction TimeResistanceResponse RTResponse TimeRodentRodentiaRodents MammalsRoleSingle-Nucleus SequencingStress and CopingSubstantia NigraSubstantia nigra structureSystemTime PerceptionVentral Tegmental Areaaldehyde dehydrogenasesbehavior testbehavioral testbody movementcalbindincoping with stressdesigner receptors exclusively activated by designer drugsdisease modeldisorder modeldopaminergic neuronendocannabinoid signalingflexibilityflexiblegenetic approachgenetic strategyknockin micelocomotor controllocomotor learningmotor controlmotor diseasemotor disordermotor dysfunctionmotor learningmotor skill learningneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronalneuronal degenerationpars compactapathwayperceptual motor learningprogramspsychomotor reaction timeresistantreward processingsNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolestress-related copingtherapeutic targetventral tegmentum
Description preview
Parkinson’s disease (PD) is pathologically characterized by the progressive loss of midbrain dopaminergic neurons (DANs), particularly those in the substantia nigra pars compacta (SNc). We and others have shown that aldehyde dehydrogenase 1A1-positive (ALDH1A1+) DANs in the ventral tier of the SNc are especially vulnerable in individuals with PD,…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click