grant
Alam Project
Organization UNIVERSITY OF KENTUCKYLocation LEXINGTON, UNITED STATESPosted 1 Mar 2020Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY20251,5-PentanediamineAIDPAcute Autoimmune NeuropathyAcute Infective PolyneuritisAcute Inflammatory Demyelinating PolyradiculoneuropathyAcute Inflammatory PolyneuropathyAcute Inflammatory PolyradiculoneuropathyAdherenceAffectAffinityAnabolismAnimalsAnti-Bacterial AgentsAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibiotic susceptibilityAntibioticsAssayAttenuatedBacterial InfectionsBindingBioassayBiological AssayBiologyC jejuniC. jejuniCOBRECadaverineCampylobacter infectionCampylobacter jejuniCampylobacteriosisCell Communication and SignalingCell SignalingCenter of Biomedical Research ExcellenceCenters of Research ExcellenceChemicalsChemistryChemoreceptorsChemotaxisChemotaxis InhibitionColitisCollaborationsColorectal CancerDiseaseDisorderDrug TargetingE coliE. coliEnteralEntericEnterocytesEnzyme GeneEnzymesEpithelial CellsEpitheliumEscherichia coliFecesFormulationFunctional MetagenomicsGI microbiomeGI microbiotaGastrointestinal microbiotaGeneral TaxonomyGeneralized GrowthGrowthGuillain Barré SyndromeGuillaine-Barre SyndromeGut MucosaHealthHumanInfectionInflammationInflammatoryInfrastructureIntermediary MetabolismIntestinalIntestinal MucosaIntestinesIntracellular Communication and SignalingInvadedIrritable Bowel SyndromeIrritable ColonKnowledgeL-LysineLandry's paralysisLandry-Guillain-Barre SyndromeLate-Onset DisorderLeadLigand BindingLigandsLysineLysine decarboxylaseMediatingMentorshipMetabolic ProcessesMetabolismMetagenomicsMiceMice MammalsMiscellaneous AntibioticModern ManMolecular InteractionMotilityMucosaMucosal TissueMucous ColitisMucous MembraneMurineMusPathogenesisPb elementPentamethylenediaminePeptidesPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePolyamine CompoundPolyaminesProductionProteinsProteobacteriaPublic HealthPurple BacteriaReceptor ProteinReportingResistanceResistance to antibioticsResistant to antibioticsRoentgen RaysScienceSignal TransductionSignal Transduction SystemsSignalingStructureSystemTaxonomyTestingTissue GrowthToxic effectToxicitiesToxinTransducersUnited StatesValidationVirulenceVirulentX-RadiationX-Ray RadiationX-rayXrayacid stressacute idiopathic polyneuritisacute post-infectious polyneuropathyacute postinfectious polyneuropathyanti-bacterialantibiotic drug resistanceantibiotic resistantattenuateattenuatesbacteria infectionbacterial diseasebiological signal transductionbiosynthesisbowelbowel inflammationcadA lysine decarboxylasecytokinedesigndesigningdigestive tract microbiomedrug developmentdruggable targetdysbacteriosisdysbiosisdysbioticeconomic costenteral infectionenteric infectionenteric microbial communityenteric microbiomeenteric microbiotaenteric pathogen infectionenteropathogen infectionenteropathogenic infectiongastrointestinal infectiongastrointestinal microbial floragastrointestinal microbiomegut communitygut floragut inflammationgut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomeheavy metal Pbheavy metal leadhumanized micehumanized mousein vitro activityindexinginfected with enteropathogeninflamed bowelinflamed gutinflamed intestineinhibitorinnovateinnovationinnovativeinsightintestinal biomeintestinal epitheliumintestinal floraintestinal infectionintestinal inflammationintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraintestine infectionlate disease onsetlate onset disordermetabolism measurementmetabolomicsmetabonomicsmetaproteomicsmicrobialmicrobial consortiamicrobial floramicrobial imbalancemicrobiotamicrofloramouse modelmultispecies consortiamurine modelmutantnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetontogenypathogenpharmaceuticalprototypereceptorreconstitutereconstitutionresistantscreeningscreeningssmall moleculespastic colonstooltargeted agentvalidationsvirtual
Description preview
PROJECT SUMMARY – PROJECT 7 (ALAM)
Campylobacter jejuni is the primary pathogen responsible for bacterial gastrointestinal infections worldwide and
is the leading cause of enteric inflammation in the United States, which can further lead to late-onset diseases
such as Guillain Barré Syndrome, colorectal cancers, IBD, and IBS. Importantly, C.…
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