grant
AI-assisted quantitative photon-counting-detector CT imaging for cytogenetic risk prediction and treatment response in multiple myeloma
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 1 Apr 2025Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025AI AugmentedAI assistedAI basedAI based modelAI drivenAI enhancedAI integratedAI modelAI poweredAI systemAberrant ChromosomeAccuracy of DiagnosisAlgorithmsArtificial IntelligenceArtificial Intelligence enhancedAugmented by AIAugmented by the AIAugmented with AIAugmented with the AIBMCELLTYBiological MarkersBiopsyBlood Plasma CellBone MarrowBone Marrow AspirationBone Marrow CellularityBone Marrow InvolvementBone Marrow Reticuloendothelial SystemBone marrow biopsyCAT scanCT X RayCT XrayCT imagingCT scanChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome abnormalityClinicalComplexComputed TomographyComputer ReasoningCytogenetic AberrationsCytogenetic AbnormalitiesCytogenetic AnalysisCytogenetic TechnicsCytogenetic TechniquesCytogeneticsDataDetectionDevelopmentDiagnosisDiseaseDisease ManagementDisorderDisorder ManagementDoseFDA approvedFISH TechnicFISH TechniqueFISH analysisFISH assayFatsFatty acid glycerol estersFluorescence In Situ HybridizationFluorescent in Situ HybridizationGenomicsGoalsImageImaging ProceduresImaging TechnicsImaging TechniquesLesionLyticLytic LesionMR ImagingMR TomographyMRIMRIsMachine IntelligenceMagnetic Resonance ImagingMalignantMalignant - descriptorMarrowMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethodsModelingMolecular Cytogenetic TechnicsMolecular Cytogenetic TechniquesMonitorMorphologyMultiple MyelomaNMR ImagingNMR TomographyNeeds AssessmentNewly DiagnosedNuclear Magnetic Resonance ImagingOutcomePETPET ScanPET imagingPET/CTPET/CT scanPETSCANPETTPathway interactionsPatient CompliancePatientsPerformancePhysicsPlasma CellsPlasma-Cell MyelomaPlasmacytesPositionPositioning AttributePositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPredicting RiskPrognosisProgression-Free SurvivalsProtocolProtocols documentationRad.-PETResearchResolutionRetrospective cohortRiskSamplingScanningSkeletonSystemTechnologyTestingTimeTomodensitometryTreatment EfficacyVertebral BodyWorkX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyZeugmatographyartificial intelligence assistedartificial intelligence augmentedartificial intelligence basedartificial intelligence drivenartificial intelligence integratedartificial intelligence modelartificial intelligence poweredartificial intelligence-based modelaspiratebio-markersbiologic markerbiomarkerboneburden of diseaseburden of illnesscatscanchemotherapychromosomal defectchromosome defectclinical significanceclinically significantcohortcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographycostcytogenetic assaycytogenetic assessmentcytogenetic methodcytogenetic methodologycytogenetic testingdeep learningdeep learning based modeldeep learning methoddeep learning modeldeep learning strategydevelopmentaldiagnosis standarddiagnostic accuracydisease burdendisease heterogeneityenhanced with AIenhanced with Artificial Intelligenceexperienceforecasting riskimage processingimage-based methodimagingimaging biomarkerimaging markerimaging methodimaging modalityimaging-based biological markerimaging-based biomarkerimaging-based markerimprovedin vivoinnovateinnovationinnovativeintervention efficacylow dose computed tomographylow dose computerized tomographylow-dose CTmulti-modalitymultimodalitymyelomamyelomatosisnon-contrast CTnoncontrast CTnoncontrast computed tomographypathwaypatient adherencepatient cooperationpatient prognosisperformance testsphoton detectionphoton-counting detectorplasmocytepositron emission computed tomographypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypredict responsivenesspredict riskpredict riskspredicted riskpredicted riskspredicting responsepredicting riskspredictive riskpredicts riskprognosis modelprognostic modelprognosticationresolutionsresponseresponse to therapyresponse to treatmentrisk predictionrisk prediction algorithmrisk prediction modelrisk predictionsrisk stratificationsingle photon detectorskeletonsstratify risktherapeutic efficacytherapeutic responsetherapy efficacytherapy responsetooltreatment choicetreatment responsetreatment responsivenessvertebra bodywhole body imagingwhole body scanning
Description preview
PROJECT SUMMARY/ABSTRACT
Focal bone marrow biopsies of the posterior iliac crest are the gold standard for diagnosing multiple
myeloma, yet they do not reflect the spatial and genomic heterogeneity of the disease. Almost 25% of
such patients do not have adequate samples for cytogenetic assessment need for risk stratification.
This inconsistency in…
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