grant
Aging and transplant immunity
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 3 May 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AddressAffectAgingAntibodiesAntibody ResponseAttenuatedB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBiologyCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCardiac TransplantationCell AgingCell BodyCell Mediated ImmunologyCell SenescenceCell-Mediated ImmunityCellsCellular AgingCellular ImmunityCellular Metabolic ProcessCellular SenescenceClinicalClinical ResearchClinical StudyCollaborationsDataDendritic CellsDevelopmentDiseaseDisorderDrugsEnvironmentExclusionFOXP1FOXP1 geneForkhead Box P1Gene TranscriptionGenetic TranscriptionGlnGlutamate MetabolismGlutamate Metabolism PathwayGlutamineGlutamine-Rich Factor 1GoalsGraft SurvivalGrafting ProcedureHeart GraftingHeart TransplantationImmuneImmune ToleranceImmune mediated therapyImmune responseImmune systemImmunesImmunityImmunologic ToleranceImmunologically Directed TherapyImmunomodulationImmunosuppressantsImmunosuppressionImmunosuppression EffectImmunosuppressive AgentsImmunosuppressive EffectImmunosuppressive drugImmunosuppressive treatmentImmunotherapyInflammagingInflammatoryInvestigatorsL-GlutamineLifeLife ExpectancyLymph Node Reticuloendothelial SystemLymph node properLymphatic nodesLymphotoxinLymphotoxin ALymphotoxin-alphaLymphotoxin-αManuscriptsMediatingMedicationMember 1 TNF SuperfamilyMetabolicMiceMice MammalsMicrosurgeryMolecularMurineMusNanodeliveryNephrotoxicOlder PopulationOrganOrgan TransplantationOrgan TransplantsOutcomePathogenesisPathogenicityPathway interactionsPharmaceutical PreparationsPositionPositioning AttributeProcessProtocolProtocols documentationPublishingQ LevoglutamideQ. LevoglutamideQRF1RNA ExpressionReceptor SignalingRegulationRejuvenationReplicative SenescenceResearch PersonnelResearchersResistanceReticular CellRoleScientistSiteSolidStressT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsT4 CellsT4 LymphocytesTNF-bTNF-betaTNF-βTNFSF1TNFβTechnologyTestingTimeTranscriptionTransplant RecipientsTransplantationTransplantation SurgeryTumor Necrosis Factor-BetaTumor Necrosis Factor-βVeiled CellsWorkage associatedage associated alterationsage associated changesage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage specificage specific alterationsage specific changesage-related inflammationagedaged groupaged groupsaged individualaged individualsaged miceaged mouseaged peopleaged personaged personsaged populationaged populationsaging associated alterationsaging associated changesaging associated inflammationaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging populationaging related alterationsaging related changesaging specific alterationsaging specific changesalloimmunityalterations with ageanti-viral immunityantibody rejectionantibody-mediated rejectionantiviral immunityattenuateattenuatescardiac graftcell metabolismcellular metabaolismchanges with agecohortcollaborative approachdesigndesigningdetermine efficacydevelopmentaldrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationelderly miceelderly patientevaluate efficacyexamine efficacyheart transplanthost responseimmune imagingimmune modulating strategyimmune modulationimmune modulatory strategyimmune regulationimmune suppressionimmune suppressive activityimmune suppressive agentimmune suppressive functionimmune suppressorimmune system responseimmune system toleranceimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune unresponsivenessimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoimagingimmunologic reactivity controlimmunological paralysisimmunomodulatoryimmunomodulatory strategyimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimmunosuppressive substanceimmunosuppressorimprovedinflamm-ageinginflamm-aginginflammation associated with aginginflammatory environmentinflammatory milieuinhibitorinnovateinnovationinnovativeisoimmunitykidney toxicitylymph glandlymph nodeslymphnodeslymphotoxin beta receptorlymphotoxin β receptorlymphotoxin-beta-specific receptormembermouse modelmurine modelnanonanoparticle therapynanotherapeuticnephrotoxicitynew approachesnovelnovel approachesnovel strategiesnovel strategyold miceolder groupsolder individualsolder patientolder personorgan allograftorgan graftorgan rejectionorgan transplant rejectionorgan xenograftpathwaypopulation agingreplicative agingresistantresponsesenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescentsenescent associated secretomesenescent associated secretory phenotypesenescent cellsenolyticssite targeted deliveryskillssocial rolesynergismtargeted deliverytherapeutic nanoparticlesthymus derived lymphocytetransplanttransplant modeltransplant patient
Description preview
OVERALL – SUMMARY/ABSTRACT
With an ever increasing aging population and prolonged life spans, there has been a significant increase in the
number of older transplant recipients. At the same time, older patients represent the fastest growing cohort
waiting for a transplant. Those older patients are treated in the same way as young recipients, yet…
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