grant
Age-associated changes in B cell and antibody effector responses to Streptococcus pneumoniae
Organization WAKE FOREST UNIVERSITY HEALTH SCIENCESLocation WINSTON-SALEM, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY202519S Gamma Globulin21+ years old65 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years old7S Gamma GlobulinAb responseAdoptive Cell TransfersAdultAdult HumanAffectAgeAged 65 and OverAgingAntibodiesAntibody FormationAntibody ProductionAntibody ResponseAntigensAssayB blood cellsB cellB cellsB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellBacteremiaBacteriaBehaviorBioassayBiological AssayBlood SerumBronchioalveolar LavageBronchoalveolar LavageBronchopulmonary LavageBypassC57BL/6 MouseCell BodyCell CountCell NumberCellsClinical Treatment MoabComplementComplement ActivationComplement ProteinsComplement ReceptorConfounding Factors (Epidemiology)Confounding VariablesCountryD pneumoniaeD. pneumoniaeDataDeath RateDefectDiplococcus pneumoniaeEffectivenessElderlyEnvironmentEpidemiologic Confounding FactorExhibitsExposure toFailureFrequenciesGlycansHealthHumanIgGIgG ReceptorsIgG1IgG3IgMImmuneImmune responseImmunesImmunityImmunizationImmunoglobulin GImmunoglobulin G ReceptorImmunoglobulin MImpairmentIn VitroInbred MouseIndividualInfectionInfection preventionInnate ImmunityKnowledgeLifeLobar PneumoniaLower Respiratory Tract InfectionLower respiratory infectionLower respiratory tract structureLungLung LavageLung ParenchymaLung Respiratory SystemLung TissueLung infectionsMediatingMeningitisMiceMice MammalsModern ManMonoclonal AntibodiesMurineMusNative ImmunityNatural ImmunityNon-Polyadenylated RNANon-Specific ImmunityNonspecific ImmunityNutrientPathway interactionsPersonsPhagocytesPhagocytic CellPhysiologyPneumococcal InfectionsPneumococcal PneumoniaPneumococcal vaccinePneumococcusPneumoniaPneumovaxPolysaccharidesPopulationPreclinical dataPredispositionPrevent infectionPreventative measurePreventionPreventive measureProteinsPublishingRNARNA Gene ProductsReportingRestRibonucleic AcidRiskS pneumoniaeS. pneumoniaeSerotypingSerumSmokingStreptococcus pneumoniaeStreptococcus pneumoniae InfectionsStreptococcus pneumoniae vaccineStructure of parenchyma of lungSusceptibilitySystemic diseaseT-CellsT-LymphocyteTestingTherapeuticVaccinatedVaccinationVaccination acquired immunityVaccination induced immunityVaccinesWorkabove age 65adoptive cell therapyadoptive cellular therapyadult youthadulthoodadvanced ageafter age 65age 65 and greaterage 65 and olderage 65 or olderageage associated alterationsage associated changesage associated differenceage based differenceage correlated alterationsage correlated changesage dependent alterationsage dependent changesage dependent differenceage dependent variationage differenceage induced alterationsage induced changesage of 65 years onwardage related alterationsage related changesage related differenceage related variationage specific alterationsage specific changesage specific differenceagedaged 65 and greateraged 65+aged groupaged groupsaged individualaged individualsaged miceaged mouseaged peopleaged personaged personsaged populationaged populationsaged ≥65agesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging populationaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with ageamebocyteantibody biosynthesisbacteraemiabacteria pathogenbacterial bloodstream infectionbacterial infection in the bloodstreambacterial pathogenblood infectionbloodstream infectionbronchiolar alveolar lavagebronchopulmonary lavage therapychanges with ageco-morbidco-morbiditycohortcomorbiditycomplement pathway regulationcomplementationdiffer by agedifference across agedifference in ageelderly miceelderly patientexperimentexperimental researchexperimental studyexperimentsgamma Fc Receptorsgeriatrichost responsehuman old age (65+)human pathogenimmune system responseimmunogenimmunoglobulin biosynthesisimmunoresponseimprovedinfection in the bloodinfection of the bloodlife spanlifespanlower respiratory tractmAbsmalemonoclonal Absmortality ratemortality ratiomouse modelmurine modelold miceolder adultolder adulthoodolder patientover 65 yearspathogenic bacteriapathwaypneumococcal diseasepneumococcus infectionpopulation agingpreclinical findingspreclinical informationpulmonary infectionsreceptor expressionrespiratoryresponsesenior citizenthymus derived lymphocytetreatment strategyvaccination studyvaccination trialvaccine acquired immunityvaccine associated immunityvaccine efficacyvaccine responsevaccine responsivenessvaccine strategyvaccine studyvaccine trialvaccine-induced immunityvaccine-induced protectionvaccine-induced responsevariation by ageyoung adultyoung adult ageyoung adulthood≥65 years♂
Description preview
ABSTRACT
Streptococcus pneumoniae is an opportunistic human pathogen that causes pneumococcal pneumonia, an
infection of the lower respiratory tract, as well as life-threatening bloodstream infections and meningitis. Despite
the availability and widespread administration of pneumococcal vaccines, these infections continue to
disproportionately…
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