grant
Afferent Mechanisms of Vagal Neuromodulation Therapy
Organization EAST TENNESSEE STATE UNIVERSITYLocation JOHNSON CITY, UNITED STATESPosted 1 Aug 2018Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025Action PotentialsAddressAfferent NeuronsAnimalsAntidiuretic HormoneAssayAxonBioassayBiological AssayBrainBrain Nervous SystemBrain StemBrainstemCNS DiseasesCNS Nervous SystemCNS disorderCardiovascular DiseasesCell Communication and SignalingCell SignalingCellular AssayCentral Nervous SystemCentral Nervous System DiseasesCentral Nervous System DisordersCervicalChronicCirculatory CollapseClinicalClinical ProtocolsCommon Rat StrainsCommunicationCoughingCouplesCranial Nerve XDiagnosisDrug resistanceEffectivenessEncephalonEvaluationExperimental DesignsFailureFoundationsFrequenciesGoalsHalorhodopsin ChromoproteinHalorhodopsinsHeart failureHypothalamic structureHypothalamusIn VitroIntracellular Communication and SignalingKnowledgeLightLinkMeasuresMental DepressionMinorityModelingNerveNerve CellsNerve UnitNeural CellNeural TransmissionNeuraxisNeurocyteNeuronsNeuropeptidesNucleus Tractus SolitariiNucleus solitariusOcytocinOutcomeOxytocinPainPainfulParaventricular Hypothalamic NucleusPathway interactionsPatientsPatternPeripheralPhotoradiationPhysiologyPneumogastric NervePreclinical dataProcessPropertyProtocolProtocols documentationRatRats MammalsRattusRecombinant OxytocinRecommendationResearchResolutionRoleSensorySensory NeuronsShockSignal TransductionSignal Transduction SystemsSignalingSliceSolitary NucleusStimulusSynaptic TransmissionTenth Cranial NerveTherapeuticTitrationsTransfectionTransmissionTreatment EfficacyVagus NerveVagus nerve structureVasopressinsVisceral AfferentsVoiceWorkbeta-Hypophaminebiological signal transductioncardiac failurecardiovascular disordercell assaycirculatory shockclinical applicabilityclinical applicationdepressiondesigndesigningdrug resistantevidence baseexperienceexperimentexperimental researchexperimental studyexperimentsheart failure and reduced ejection fractionheart failure with reduced ejection fractionhypothalamicimprovedinsightintervention designintervention efficacyneural controlneural regulationneuromodulationneuromodulatoryneuronalneuroregulationoptimal therapiesoptimal treatmentsoptogeneticsparaventricular nucleuspatch clamppathwaypre-clinicalpreclinicalpreclinical findingspreclinical informationrecruitresistance to Drugresistant to Drugresolutionsshocksside effectskillssocial rolesolitary tract nucleussuccesssynaptic depressiontherapeutic efficacytherapeutic outcometherapeutically effectivetherapy designtherapy efficacytherapy outcometooltransmission processtreatment design
Description preview
1 Project Summary
2
3 Vagal nerve stimulation (VNS) therapy is approved for three central nervous system disorders. Despite promising
4 preclinical evidence of success amelioration of heart failure, several large patient trials have failed to meet
5 designated endpoints. Remarkably many recommended clinical protocols for VNS therapy appear to…
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