grant
Advancing Transplantation Tolerance in Nonhuman Primates
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 20 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AccelerationAddressAntibodiesApoptoticAutoimmune DiseasesBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood leukocyteBlood monocyteBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBone Marrow Stem Cell TransplantationBp50CD11bCD134CD134LCD154CD40CD40LCD40LGCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCDW40CR3ACancersCardiac DiseasesCardiac DisordersCardiovascular DiseasesCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell TherapyCellsCellular FunctionCellular PhysiologyCellular ProcessChronicCollaborationsDataDevelopmentDiabetes MellitusDiseaseDisorderDrugsESKDESRDEffector CellElementsEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEnvironmentFertilizationFingerprintGP34GoalsGrafting ProcedureHealthHeart DiseasesHumanIL-1IL1ITGAMITGAM geneImmuneImmune ToleranceImmune responseImmunesImmunologic ToleranceImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInfectionInflammasomeInflammationInflammatory ResponseInnate Immune ResponseInnate ImmunityInterleukin IInterleukin-1Intracellular Communication and SignalingInvestigatorsIschemia-Reperfusion InjuryKidney GraftingKidney TransplantationKidney TransplantsLeukocytesLeukocytes Reticuloendothelial SystemLymphocyte-Stimulating HormoneMAC1AMGC9013MO1AMacrophage Cell FactorMaintenanceMalignant NeoplasmsMalignant TumorMarrow NeutrophilMarrow leukocyteMarrow monocyteMediatingMedicationMemoryModern ManMorbidityMorbidity - disease rateMyeloid CellsMyeloid-derived suppressor cellsNHP modelsNanotechnologyNative ImmunityNatural ImmunityNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Specific ImmunityNonspecific ImmunityOX40OX40LOrganOrgan TransplantationOrgan TransplantsOutcomePathway interactionsPatientsPersonal SatisfactionPharmaceutical PreparationsPhasePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPropertyPublicationsPublishingRNA SeqRNA sequencingRNAseqReagentReceptor ProteinRegenerative MedicineRegimenRegulatory T-LymphocyteRenal GraftingRenal TransplantationRenal TransplantsReperfusion DamageReperfusion InjuryResearchResearch PersonnelResearchersRoleScientific PublicationSignal TransductionSignal Transduction SystemsSignalingSolidSubcellular ProcessSystemT Helper FactorT cell responseT memory cellT-Cell ActivationT-CellsT-LymphocyteT8 CellsT8 LymphocytesTNFRSF5TNFRSF5 geneTNFSF4TNFSF4 geneTNFSF5TNFSF5 geneTRAP GeneTXGP1TechniquesTestingTherapeuticTissuesTransplant RecipientsTransplantationTransplantation ToleranceTregTumor Necrosis Factor Receptor Superfamily Member 5 GeneWhite Blood CellsWhite Cellactivate T cellsadaptive immune responseadaptive immunityalloimmunityantigen-specific T cellsautoimmune conditionautoimmune disorderautoimmunity diseasebiological signal transductioncardiovascular disordercell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapyclinical applicabilityclinical applicationclinical relevanceclinically relevantdesigndesigningdevelopmentaldiabetesdigitaldrug/agentfertilizationsheart disorderhost responseimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune system toleranceimmune unresponsivenessimmunologic reactivity controlimmunological paralysisimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive myeloid cellsimmunosuppressive responseimprovedindustrial partnershipindustry partnerindustry partnershipinnovateinnovationinnovativeinsightinterestisoimmunitykidney txlymphocyte activating factormalignancymemory T lymphocytemigrationmonocytemortalitymyeloid suppressor cellsmyeloid-derived suppressive cellsnano particle deliverynano technano technologynano-technologicalnanoparticle deliverednanoparticle deliverynanotechnanotechnologicalneoplasm/cancerneutrophilnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generationnext generation therapeuticsnon-human primatenonhuman primatenonhuman primate modelsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyorgan allograftorgan graftorgan xenograftp50pathwaypreventpreventingprogramsprospectivereceptorregulatory T-cellsresponsescATAC sequencingscATAC-seqside effectsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell sequencing assay for transposase accessible chromatinsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsocial rolestem cell bone marrow transplantationsuppressive myeloid cellssynergismtherapeutic targetthymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingtransplanttransplant patientwell-beingwellbeingwhite blood cellwhite blood corpuscle
Description preview
While short-term outcomes following organ transplant have greatly improved with the development of more
effective immunosuppression, long-term outcomes remain problematic with a significant number of patients
developing diabetes, accelerated heart disease as well as increased rates of cancers and infections. For
decades transplant researchers and…
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