grant
Advancing Transplantation Outcomes in Children
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 7 Sept 2021Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20250-11 years old2-arm trial2019 novel corona virus2019 novel coronavirus2019-nCoV21+ years oldATGAMActive Follow-upAcuteAddressAdoptedAdultAdult HumanAlloantibodiesAllograftingAnti-Rejection TherapyAntibody ResponseAntithymocyte GlobulinAntithymoglobulinAreaAssayBindingBioassayBiological AssayBiological MarkersBiopsyBurkitt HerpesvirusBurkitt Lymphoma VirusCOVID-19 virusCOVID19 virusCaringCell BodyCell CommunicationCell InteractionCell-to-Cell InteractionCellsCessation of lifeChildChild YouthChildhoodChildren (0-21)ChronicClinicalClinical TrialsCoV-2CoV2CollaborationsCreatinineDataData BasesDatabasesDeathDevelopmentDiagnosticDonor personDysfunctionEB virusEBVESKDESRDEducationEducational aspectsEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEnrollmentEpstein Barr VirusEvaluationExposure toFailureFunctional disorderFutureGenesGenomicsGenotypeGoalsGraft SurvivalGrafting ProcedureHHV-4HHV4Helper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHospital AdmissionHospitalizationHuman Herpesvirus 4ImmuneImmune responseImmunesImmunityImmunobiologyImmunomodulationImmunophysiologyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunosuppressive TherapyInducer CellsInducer T-LymphocytesInduction TherapyInfectionInfectious AgentInfectious Mononucleosis VirusInflammationInvestigatorsIsoantibodiesKidney GraftingKidney TransplantationKidney TransplantsKnowledgeLaboratoriesLifeLife ExpectancyLiving DonorsMaintenanceMaintenance TherapyMediatingMemory B CellMemory B-LymphocyteMolecular InteractionMonitorMorbidityMorbidity - disease rateNEOADJNeoadjuvantNeoadjuvant TherapyNeoadjuvant TreatmentOpportunistic InfectionsOrgan TransplantationOrgan TransplantsOutcomePatientsPatternPerformancePhysiopathologyPilot ProjectsPopulationProcessProductionProteinsRandomizedRapamuneRapamycinRegimenRenal GraftingRenal TransplantationRenal TransplantsRenal functionResearch PersonnelResearchersRiskSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SchoolsSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2Signal PathwaySirolimusSolidSurvival RateT-CellsT-LymphocyteTacrolimusTestingTherapeutic AgentsTherapeutic immunosuppressionThymoglobulinTransplant RecipientsTransplant immunologyTransplantationTransplantation ImmunologyUrineVaccinesViral DiseasesVirusVirus DiseasesWuhan coronavirusactive followupadulthoodage associatedage correlatedage dependentage linkedage relatedage specificagedallograft rejectionalloimmunityarmartificial immunosuppressionbio-markersbiologic markerbiomarkerchild patientsclinical centerclinical significanceclinically significantcoronavirus disease 2019 viruscoronavirus disease-19 virusdata basedata registrydeceased donordeceased organ donorsdetermine efficacydevelopmentalefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationenrollevaluate efficacyexamine efficacyexperiencefollow upfollow-upfollowed upfollowupgenome scalegenome-widegenomewidegraft functionhCoV19host responseimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppression therapyimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedinduction therapiesinfectious organisminnovateinnovationinnovativeinsightintervention armisoimmunitykidney functionkidney txkidsmTOR Inhibitormortalitymycophenolate mofetilmycophenolic acid morpholinoethyl esternCoV2new drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynovel virusopen labelopen label studyorgan allograftorgan graftorgan xenograftpathogenpathophysiologypediatricpediatric patientspilot studypoint of carepost-transplantpost-transplantationposthumous donorsposthumous organ donorposttransplantposttransplantationprediction algorithmpreservationpreventpreventingprimary end pointprimary endpointrandomisationrandomizationrandomly assignedresponseseropositivestandard of carethymus derived lymphocytetooltranscriptomicstransplanttransplant centerstransplant donortransplant patienttreatment armtreatment choicetwo-arm trialurinaryvaccine antibodiesvaccine induced antibodiesvaccine-induced antibodiesviral infectionvirtualvirus infectionvirus-induced diseaseyoungster
Description preview
Project Summary/Abstract
Renal transplantation is widely recognized as the treatment of choice for children with end stage renal
disease (ESRD). The life expectancy benefit is significant and a functioning renal transplant enables
children to grow well, develop almost normally and improve their school educational performance levels.
However,…
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