grant
Advancing Sepsis Biology and Care Through the Power of Modern Biobanks
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 15 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AccountingAffectBehavioralBiologicalBiologyCaringClinicalClinical TrialsCollaborationsComplexDataDiathesisDiseaseDisease susceptibilityDisorderDrugsEconomic BurdenElectronic Health RecordEpidemiologyGene variantGeneticGoalsHealthHistorical DemographyHospital AdmissionHospital MortalityHospitalizationHumanImmune mediated therapyImmunologically Directed TherapyImmunotherapyIn-house MortalitiesInhospital MortalityKnowledgeLaboratoriesLinkMeasurementMedicationModern ManModernizationMolecularMorbidityMorbidity - disease rateOutcomePathogenesisPathway interactionsPatientsPharmaceutical PreparationsPhenotypePhysiologicPhysiologicalRegulationReproducibilityResearchResearch ResourcesResourcesRiskRisk FactorsRisk-associated variantRoleRunningSepsisSeverity of illnessShapesTestingVariantVariationWorkallelic variantbiobankbiologicbiorepositorycase controlcase-controlledclinical careclinical heterogeneityclinical riskco-morbidco-morbiditycomorbiditydata diversitydisease riskdisease severitydisorder riskdiverse datadrug developmentdrug/agentelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordepidemiologicepidemiologicalexperimentexperimental researchexperimental studyexperimentsfunctional genomicsgenetic analysisgenetic associationgenetic variantgenomic datagenomic datasetgenomic varianthealth datahuman genomicsimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyindividuals with sepsisliability to diseasemolecular phenotypemortalitynew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnon-geneticnongeneticnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpathwaypatients with sepsispeople with sepsisphenotypic dataprogramsresponserisk allelerisk generisk genotyperisk locirisk locusrisk variantsepsis groupssepsis patientssepsis populationsepsis subjectsseptic groupseptic individualsseptic patientsseptic peopleseptic populationseptic subjectsocialsocial determinantssocial health determinantssocial rolesocio-demographicssociodemographicssociodeterminantsubjects with sepsistool
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PROJECT SUMMARY
Sepsis is a leading cause of hospital admission and mortality worldwide, posing a significant economic burden.
Despite extensive efforts and numerous clinical trials over the past 30 years, no approved drugs for sepsis exist,
largely due to inadequate knowledge of the factors that contribute to sepsis clinical heterogeneity and a…
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