grant
Advancing sacral neuromodulation with objective analytics and prediction
Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AbscissionAcuteAddressAdoptionAffectAgeAnatomic SitesAnatomic structuresAnatomyAnogenital regionAreaArticulationBiomedical EngineeringBladderBladder Urinary SystemBrainBrain Nervous SystemCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell Communication and SignalingCell SignalingClinicalComputer ModelsComputerized ModelsCutaneousDataDevelopmentDevicesDrug TherapyDrugsDysfunctionEncephalonEngineeringEsthesiaExcisionExtirpationExtravasationFrequenciesFunctional disorderFundingGoalsHemoglobinHydrationHydration statusImplantInterruptionIntracellular Communication and SignalingInvestigatorsK-AwardsK-Series Research Career ProgramsLeadLeakageLocationMapsMeasuresMedicationMentorsMentorshipMethodsModelingMorbidityMorbidity - disease rateMotorNational Institutes of HealthNerveNerve Impulse TransmissionNerve TransmissionNeurologicNeurologicalNeuronal TransmissionOperative ProceduresOperative Surgical ProceduresOutcomeOveractive BladderParticipantPatientsPatternPb elementPelvicPelvic RegionPelvisPerineumPersonsPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhysiciansPhysiopathologyPopulationPrefrontal CortexProtocolProtocols documentationProviderQOLQuality of lifeRefractoryRemovalReportingResearchResearch Career ProgramResearch PersonnelResearchersRoleSacral nerveSensationSensorySensory ThresholdsSeveritiesSignal TransductionSignal Transduction SystemsSignalingSpillageStandardizationStructureSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSymptomsTabletsTechnical ExpertiseTechniquesTestingTimeTrainingUnited States National Institutes of HealthUrge IncontinenceUrgency to pass urineUrgent desire to urinateUrinationUrologyWomanWorkagesaxon signalingaxon-glial signalingaxonal signalingbio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductionbrain oxygenationcareercerebral oxygenationclinical predictorscompare to controlcomparison controlcomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputerized modelingcostcost effectivenesscustomized therapycustomized treatmentdesigndesigningdevelopmentaldrug interventiondrug treatmentdrug/agentfNIRSfunctional near infrared spectroscopyglia signalingglial signalingheavy metal Pbheavy metal leadimplantationimprovedindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinnovateinnovationinnovativeinstrumentmenmicturitionmicturition urgencymultidisciplinarynerve signalingneuralneural controlneural regulationneural signalingneuromodulationneuromodulatoryneuronal signalingneuroregulationneurotransmissionnovelpathophysiologypatient specific therapiespatient specific treatmentpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspredictive modelingpressurepreventpreventingprogramsreal time modelrealtime modelresectionresponseresponse to therapyresponse to treatmentresponsible research conductsensory inputside effectskillssocial rolesuccesssurgerytailored medical treatmenttailored therapytailored treatmenttechnical skillstherapeutic responsetherapy optimizationtherapy responsetooltreatment effecttreatment optimizationtreatment responsetreatment responsivenessunique treatmenturinaryurinary bladderurinary urgencyurination urgency
Description preview
PROJECT SUMMARY
Urinary urgency is the defining symptom in Overactive Bladder (OAB) which affects nearly 25% of the US
population and proportionately more women than men. Current treatments for OAB are lacking with the majority
of patients quickly withdrawing from drug treatments due to poor efficacy or side effects. When initial treatments
fail,…
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