grant
Advancing Precision Medicine for ARDS and Sepsis
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2032
NIHUS FederalResearch GrantFY2025AddressAdrenal Cortex HormonesAwardBiologicalCause of DeathClinicalClinical DataClinical ResearchClinical StudyClinical TreatmentClinical TrialsCollaborationsCorticoidsCorticosteroidsCritical CareCritical IllnessCritically IllData BasesDatabasesDiagnosisDiagnostic FindingsDrug TherapyExperimental ModelsFluid TherapyFoundationsFunctional MetagenomicsGoalsHandHeterogeneityHospital MortalityHumanImmune responseIn-house MortalitiesInfectionInflammatoryInhospital MortalityInvestigatorsLifeMechanical ventilationMedicineMetagenomicsModelingModern ManNHLBINational Heart, Lung, and Blood InstituteOutcomePathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPharmacological TreatmentPharmacotherapyPhenotypePlasma ProteinsPositionPositioning AttributeProspective StudiesRecoveryResearchResearch PersonnelResearchersSamplingSepsis and ARDSSigns and SymptomsSimvastatinSupportive TherapySupportive careSyndromeSynvinolinTherapeutic AgentsTimeTranslational ResearchTranslational Scienceactivated Protein Cacute respiratory distress syndrome caused by sepsisbiologicbiological heterogeneitybody fluid balance therapyclinical careclinical heterogeneityclinical interventionclinical therapycohortdata basedata modelingdrug interventiondrug treatmentdruggable targeteffective therapyeffective treatmentexperiencehandshigh dimensional datahost responseimmune system responseimmunoresponseimprovedimproved outcomein silicoin vivoinnovateinnovationinnovativemechanical respiratory assistmechanically ventilatedmodel of datamodel the datamodeling of the datamolecular phenotypemultidimensional datamultidimensional datasetsnew approachesnovelnovel approachesnovel strategiesnovel strategypathogenpathwaypatient oriented outcomespharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspre-clinical studyprecision medicineprecision-based medicinepreclinical studyprotein biomarkersprotein markersresponseresponse to therapyresponse to treatmentsepsis ARDSsepsis acute respiratory distress syndromesepsis and acute respiratory distress syndromesepsis associated acute respiratory distress syndromesepsis induced ARDSsepsis induced acute respiratory distress syndromesepsis related acute respiratory distress syndrometargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapy responsetraittranslation researchtranslational investigationtreatment effecttreatment responsetreatment responsivenesstrial regimentrial treatment
Description preview
Abstract:
The acute respiratory distress syndrome (ARDS) and sepsis are common causes of death in critically ill
patients, yet both are clinical syndromes defined by non-specific signs and symptoms which encompass major
clinical and biological heterogeneity. Pre-clinical studies have identified numerous promising therapeutic agents
for both ARDS…
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