grant
Advancing neurodevelopmental outcome prediction in children exposed to HIV using clinical features and placental imaging
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 6 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20260-11 years old1 year of age1 year old3-D3-Dimensional3D5 year old5 years of ageAI algorithmAI based modelAI modelAI systemAIDS VirusASDAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActive Follow-upAddressAffectAmnionitidesAnemiaAnti-Retroviral AgentsArtificial IntelligenceAutismAutistic DisorderBioinformaticsBirthBlood - brain barrier anatomyBlood VesselsBlood-Brain BarrierBrainBrain Nervous SystemCaringCells Placenta-TissueCerebral PalsyChildChild Development DisordersChild HealthChild YouthChildhoodChildren (0-21)ChorioamnionitisChronicClinicalClinical DataCollectionComplexComputer ReasoningCountryDataDeveloping fetusDevelopmentDevelopmental DisabilitiesDiagnosisDiscipline of obstetricsDysfunctionEarly Infantile AutismEarly InterventionEarly identificationEncephalonEnrollmentEventExposure toFetal DevelopmentFunctional disorderGeneralized GrowthGestationGoalsGrowthHIVHIV InfectionsHIV individualsHIV infected individualsHIV infected personsHIV peopleHIV positive individualsHIV positive peopleHIV viral infectionHIV virus infectionHIV-1 infectionHealthHemato-Encephalic BarrierHistologicHistologicallyHistopathologyHistoryHouseholdHuman Immunodeficiency VirusesImageImaging ProceduresImaging TechnicsImaging TechniquesImpairmentInfantile AutismInfection by HIV-1Infection from HIV-1Infection of HIV-1Infection of amniotic cavityInfection of amniotic sac and membranesInflammationInfrastructureInvestigatorsKanner's SyndromeLAV-HTLV-IIILaboratoriesLifeLinkLongitudinal StudiesLongitudinal SurveysLymphadenopathy-Associated VirusMachine IntelligenceMalariaMediatingMediationMedicalMethodsModelingMothersNational Institutes of HealthNegotiatingNegotiationNeural DevelopmentNeurodevelopmental DeficitNeurologicNeurologicalNormal PlacentomaObstetricsOutcomePLWHPWHPaludismParturitionPathologyPatternPhysiopathologyPlacentaPlacenta Embryonic TissuePlacentomePlasmodium InfectionsPlayPositionPositioning AttributePredictive ValuePregnancyPregnant WomenRecording of previous eventsRegimenResearchResearch InfrastructureResearch PersonnelResearchersRiskSample SizeSamplingSouth AfricaStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStructureTissue GrowthTrainingUgandaUnited States National Institutes of HealthVillousVirus-HIVVisualWorkactive followupage 1age 1 yearage 5age 5 yearsaged 1 yearaged one yearangiogenesisanti-retroviralantiretroviral therapyantiretroviral treatmentartificial intelligence algorithmartificial intelligence modelartificial intelligence-based modelautism spectral disorderautism spectrum disorderautistic spectrum disorderbiobankbiorepositorybloodbrain barrierco-infectionco-morbidco-morbiditycohortcoinfectioncomorbiditycomputer based predictiondensitydesigndesigningdevelopmentaldevelopmental psychologyefavirenzenrollexpectant motherexpectant womenexpecting motherexpecting womenfetalfive year oldfive years of agefollow upfollow-upfollowed upfollowuphealth datahigh riskhistorieshuman immunodeficiency virus infectionimagingimprovedindexingindividuals infected with HIVindividuals who are pregnantindividuals with HIVindividuals with human immunodeficiency virusinfected with HIVinfected with human immunodeficiency virusinnovateinnovationinnovativeintra-amniotic infectionintraamniotic infectionkidslong-term studylongitudinal outcome studieslongitudinal research studymultidisciplinaryneurodevelopmentoffspringone year of ageone year oldontogenyoutcome predictionpathophysiologypediatricpeerpeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople who are pregnantpeople with HIVpeople with human immunodeficiency viruspredictive modelingpregnant femalespregnant motherspregnant peoplepregnant populationsprospectivesocio-demographicssociodemographicsstatistical analysisthose who are pregnantthree dimensionalvascularwomen who are pregnantyoungster
Description preview
PROJECT SUMMARY
More than one million children who are HIV-exposed but uninfected (CHEU) are born to pregnant people with
HIV (PPHIV) every year. CHEU have a higher risk of adverse early-life outcomes than HIV-unexposed peers,
including neurodevelopmental deficits and a >2-fold risk of growth stunting. The pathophysiology of adverse
CHEU outcomes…
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