grant
Advancing gastric cancer precision medicine in Latinos through patient-derived modeling
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-KinaseAddressAfrican AmericanAfro AmericanAfroamericanAssayBioassayBiological AssayCTEPCaliforniaCancer BurdenCancer CauseCancer EtiologyCancer ModelCancer PatientCancer Therapy Evaluation ProgramCancer TreatmentCancerModelCancersCaucasian FemalesCaucasian WomenCaucasian maleCaucasian menCell CycleCell Division CycleChemotherapy ProtocolChemotherapy RegimenChemotherapy-Oncologic ProcedureClinical ResearchClinical StudyClinical TrialsCollectionCombination Chemotherapy RegimenComplexComprehensive Cancer CenterDNA mutationDataDeath RateDevelopmentDiagnosisDisparitiesDisparityDrug CombinationsDrug ModelingsDrugsEthnic GroupEthnic OriginEthnic PeopleEthnic PopulationEthnic individualEthnicityEthnicity PeopleEthnicity PopulationEuropeanFDA approvedFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FrequenciesFundingGastric Body CancerGastric CancerGastric Cardia CancerGastric Fundus CancerGastric NeoplasmsGastric Pylorus CancerGastric TumorGenerationsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomeGenomicsGoalsHigh PrevalenceIn VitroIncidenceIndigenous AmericanIndividuals from minorityIndividuals of minorityInfrastructureInvestigatorsKinasesKnowledgeLatina PopulationLatina femalesLatina womenLatina/e womenLatina/x womenLatinasLatine femalesLatine womenLatinoLatino PopulationLatino femalesLatino groupLatino individualLatino maleLatino menLatino peopleLatino womenLatinosLatinx femalesLatinx manLatinx menLatinx womenLung NeoplasmsLung TumorMalignant Gastric NeoplasmMalignant Gastric TumorMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMechanistic Target of RapamycinMedicationMedicineMinorityMinority GroupsMinority PeopleMinority PopulationMinority individualModelingMolecular TargetMutateMutationNational Cancer BurdenOrganoidsPDX modelPI-3 KinasePI-3K/AKTPI3-KinasePI3CGPI3K-AlphaPI3K/AKTPI3KGammaPI3kPIK3PIK3-AlphaPIK3CAPIK3CA genePIK3CGPIK3CG genePTK ReceptorsPathway interactionsPatient derived xenograftPatientsPatternPharmaceutical PreparationsPhosphatidylinositol 3-KinasePhosphatidylinositol 3-Kinase, Catalytic, 110-kD, AlphaPhosphatidylinositol 3-Kinase, Catalytic, AlphaPhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePhosphotransferase GenePhosphotransferasesPopulationPtdIns 3-KinasePulmonary NeoplasmsQuimioterapiaRAFT1RaceRacesRacial GroupReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneResearchResearch PersonnelResearchersResistanceSignal PathwaySomatic MutationStomach CancerStomach NeoplasmsStomach TumorTCGATestingTexasThe Cancer Genome AtlasTranslatingTranslational ResearchTranslational ScienceTransmembrane Receptor Protein Tyrosine KinaseTransphosphorylasesType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsUniversitiesWhite FemalesWhite WomenWorkanti-cancer therapycancer cell genomecancer chemotherapycancer disparitycancer genomecancer genomicscancer health disparitycancer therapycancer typecancer-directed therapycancer-related health disparitycandidate biomarkercandidate identificationcandidate markerchemotherapydepositorydevelopmentaldisparities in mortalitydisparity in cancerdrug/agentethnic minorityethnic subgroupethnicity groupexome sequencingexome-seqexpression subtypesgastric malignancygenome mutationgenomic datagenomic datasethigh riskin vivoindividualized cancer careindividualized oncologyinhibitorkinase inhibitorlatinx malemTORmalignancymalignant stomach neoplasmmalignant stomach tumormammalian target of rapamycinminority patientmolecular sub-typesmolecular subsetsmolecular subtypesmortalitymortality disparitymortality ratemortality ratiomutantneoplasm/cancernew drug combinationnew drug treatmentsnew drugsnew pharmacological therapeuticnew pharmacotherapy combinationnew therapeuticsnew therapynext generation therapeuticsnovel drug combinationnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy combinationnovel therapeuticsnovel therapyoncogenomicsp110-Alphapathwaypatient derived xenograft modelpatients from minoritypatients of minoritypersonalized oncologypre-clinicalprecision cancer careprecision cancer medicineprecision medicineprecision oncologyprecision-based medicinepreclinicalracialracial backgroundracial minorityracial originracial populationracial subgrouprepositoryresistantresponseresponse to therapyresponse to treatmentsomatic variantstomach fundus cancerstomach pylorus cancersurvival disparitytargeted cancer therapytargeted drug therapytargeted drug treatmentstargeted drug trialstargeted pharmaceutical trialstargeted therapeutictargeted therapeutic agentstargeted therapytargeted therapy trialstargeted treatmenttargeted treatment trialstherapeutic responsetherapy responsetranslation researchtranslational investigationtreatment responsetreatment responsivenesstumortumor genometumor growthwhite malewhite men
Description preview
PROJECT SUMMARY/ASTRACT
Gastric cancer (GC) is a leading cause of cancer incidence, mortality, and survival disparities in Latinos, the
largest and youngest U.S. minority and the largest racial/ethnic group in the UCaTS states of California and
Texas. When compared to non-Latino whites (NLW), GC incidence and mortality is ~>2-fold higher in…
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