grant
Advancing Cryo-EM to Study Conformational Dynamics of Macromolecular Complexes from In Vitro to In Situ
Organization NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESLocation UNITED STATES
NIHUS FederalResearch GrantFY20252019-nCoV S protein2019-nCoV spike glycoprotein2019-nCoV spike proteinABC29ABCCABCC1ABCC1 geneAmericanAnti-viral AgentsAnticonvulsant AgentAnticonvulsant DrugsAnticonvulsantsAnticonvulsive AgentsAnticonvulsive DrugsAntigen-Antibody ComplexAntigenic DeterminantsAntigensArchitectureBinding DeterminantsBiologic ModelsBiologicalBiological FunctionBiological ModelsBiological ProcessC neoformansC. neoformansCOVID-19 S proteinCOVID-19 spikeCOVID-19 spike glycoproteinCOVID-19 spike proteinCell Communication and SignalingCell SignalingCellular RegulationCollaborationsCommunitiesComplexCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyCryptococcus neoformansData CollectionDiseaseDisorderElectron CryomicroscopyEngineeringEngineering / ArchitectureEnsureEnvironmentEpitopesEvaluationGS-XGlycoproteinsGoalsHIV-1HIV-IHIV1HealthHuman Immunodeficiency Virus Type 1Human immunodeficiency virus 1ImageImmune ComplexImmunityImmunomodulationIn SituIn VitroInfectionIntracellular Communication and SignalingIon ChannelIonic ChannelsLinkMRP1Macromolecular ComplexesMembrane ChannelsMembrane TransportMethodologyMethodsMicroscopeModel SystemModelingMolecularMolecular ConfigurationMolecular ConformationMolecular StereochemistryNational Institutes of HealthOutcomePersonsPhosphatesPhysiologicPhysiologicalPreparationProcessProteinsReceptor ProteinResearch SpecimenRoboticsSARS-CoV-2 SSARS-CoV-2 S proteinSARS-CoV-2 spikeSARS-CoV-2 spike glycoproteinSARS-CoV-2 spike proteinSamplingSecureSevere acute respiratory syndrome coronavirus 2 S proteinSevere acute respiratory syndrome coronavirus 2 spike glycoproteinSevere acute respiratory syndrome coronavirus 2 spike proteinShiga ToxinShigella CytotoxinShigella ToxinSignal TransductionSignal Transduction SystemsSignalingSpecimenStructureStx ProteinSystemTechnologyTestingTherapeuticTherapeutic FungicidesTimeToxinTransmembrane TransportTrehaloseUnited States National Institutes of HealthUniversitiesViralVirusWorkanti-fungalanti-fungal agentsanti-fungal druganti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsbiologicbiological signal transductioncell growth regulationcloud basedcomputational resourcescomputerized data processingcomputing resourcesconformationconformationalconformational conversionconformational stateconformational transitionconformationallyconformationscoronavirus disease 2019 S proteincoronavirus disease 2019 spike glycoproteincoronavirus disease 2019 spike proteincryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopydata processingdata resourcedynamic systemdynamical systemelectron cryo-tomographyexperimentexperimental researchexperimental studyexperimentsflexibilityflexibleimagingimmune modulationimmune regulationimmunogenimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimprovedinnovateinnovationinnovativeinorganic phosphateinsightinstrumentationmethod developmentmicrobialneuroactive steroidsneurosteroidsopen sourceopen source toolopen source toolkitpreparationsreceptorrobotic systemseizure drugseizure medicationspike proteins on SARS-CoV-2structural biologytechnological innovation
Description preview
In FY2025, this project advanced structural studies of macromolecular complexes across a continuum that spans purified assemblies to their native cellular environments. Using cryogenic electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET), we refined workflows that capture conformational dynamics central to processes in infection,…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click