grant
Advanced development of multi-omics based assays to predict late radiation organinjuries - the DEARE-Watch project
Organization GEORGETOWN UNIVERSITYLocation WASHINGTON, UNITED STATESPosted 19 May 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY202621+ years oldA-bombAcuteAcute Radiation SyndromeAdolescentAdolescent YouthAdultAdult HumanAdvanced DevelopmentAdverse Late EffectsAffectAgeAlgorithmic AnalysesAlgorithmic AnalysisAlgorithmsAnalyses of AlgorithmsAnalysis of AlgorithmsAnimal ModelAnimal Models and Related StudiesAnimalsAssayAtomic WarfareBenefits and RisksBioassayBiological AssayBiological MarkersBlood PlasmaBody SystemBody TissuesCardiacCause of DeathChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClassificationClinicalCohort AnalysesCohort AnalysisCohort EffectColony Stimulating Factor 3Common Rat StrainsCompanionsComputer Software ToolsComputer softwareDataDevelopmentDevice or Instrument DevelopmentDevicesDiseaseDisorderDocumentationEarly identificationEmergenciesEmergency SituationEthnic OriginEthnicityEventExposure toFDA approvedGamma RadiationGamma RaysGeneral PopulationGeneral PublicGeneral RadiologyGeneration EffectGoalsGranulocyte Colony-Stimulating FactorGraphical interfaceHeart InjuriesHigh Throughput AssayHumanIndividualInjuryInjury to KidneyInterventionIntervention StrategiesJapaneseKidneyKidney Urinary SystemLC/MSLate EffectsLate Radiation InjuryLifeLungLung Respiratory SystemLung damageMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedical SurveillanceMethodsModelingModern ManMonitorNuclear AccidentsNuclear WarfareOrganOrgan SystemPathologyPerformancePhasePlasmaPlasma SerumPluripoietinPopulationProceduresQOLQualifyingQuality of lifeRadiationRadiation AccidentsRadiation DoseRadiation Dose UnitRadiation InjuriesRadiation PneumoniaRadiation PneumonitisRadiation ToxicityRadiation exposureRadiation-Induced PneumonitisRadiologyRadiology SpecialtyRadiotoxicityRatRats MammalsRattusReportingResearchReticuloendothelial System, Serum, PlasmaRiskRisk AssessmentRisk ReductionRodent ModelRoentgen RaysSBIRSamplingSensitivity and SpecificitySmall Business Innovation ResearchSmall Business Innovation Research GrantSoftwareSoftware ToolsSpecific qualifier valueSpecifiedSurvivorsSystemSystematicsTarget PopulationsTestingTherapeutic InterventionTimeTissuesUniversitiesUrineVisualizationWorkX-RadiationX-Ray RadiationX-rayXrayadulthoodagesatom bombatomic bombautomated analysisbio-markersbiologic markerbiomarkerbiomarker arraybiomarker panelcardiac injurychronic kidney diseaseclassification algorithmclinical decision-makingcustomized therapycustomized treatmentdesigndesigningdevelopmentaldevice developmentexperiencefeasibility testinggranulocyte colony stimulating factorgraphic user interfacegraphical user interfacehigh throughput screeninghuman femalehuman subjectin-vitro diagnosticsindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinjuriesinjury to organsinstrument developmentintervention therapyirradiationirradiation injuryjuvenilejuvenile humankidney dysfunctionkidney fibrosiskidney injurylipidomicsliquid chromatography mass spectrometrylung damage after radiotherapylung damage post radiationlung injurymachine learning based modelmachine learning modelmalemarker panelmass casualtymedical countermeasuremeetingmeetingsmetabolism measurementmetabolomicsmetabonomicsminimally invasivemodel of animalmultiomicsmultiorgan injurymultiple omicsnon-human primatenonhuman primatenuclear attacknuclear disasternuclear eventnuclear incidentorgan injurypanomicspatient specific therapiespatient specific treatmentprediction algorithmpredictive assaypredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpredictive panelpredictive testprototypepulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryradiation disasterradiation eventradiation incidentradiation induced lung damageradiation lung injuryradiation poisoningradiation riskradiation-induced lung injuryradiological accidentradiological disasterradiological eventradiological incidentreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrenalrenal dysfunctionrenal fibrosisrenal injuryrisk prediction algorithmrisk prediction modelrisk-reducingsoftware toolkitsoftware user interfacestandard of caretailored medical treatmenttailored therapytailored treatmenttreatment planningunique treatmentγ-Radiationγ-Ray♂
Description preview
Abstract
Groundbreaking research has led to the successful development of countermeasures against acute radiation
toxicity, thereby significantly increasing the chance of survival of victims of a radiological accident. However,
survivors of acute radiation syndrome (ARS) are at risk for developing delayed pathologies to vital organs such
as the…
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