grant
Advanced Development of a Combined Shigella-ETEC Vaccine
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 9 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20250-11 years oldAdvanced DevelopmentAnimal ModelAnimal Models and Related StudiesAntigensAntimicrobial ResistanceArmed Forces PersonnelAttenuatedAttenuated VaccinesBiological AgentBiological ProductsChildChild YouthChildren (0-21)ChromosomesClinicalClinical EvaluationClinical TestingClinical TrialsCombination VaccinesCombined VaccinesConsultationsDataDedicationsDeveloping CountriesDeveloping NationsDevelopmentDiarrheaDiseaseDisorderDocumentationE coli VaccinesE. coli VaccinesETECEarly-Stage Clinical TrialsEngineeringEnsureEnterotoxinsEscherichia coli VaccinesExcretory functionFermentationFormulationFundingFunding MechanismsGenesGoalsGood Manufacturing ProcessGood manufacturing practiceGroups at riskHumanImmune responseIn VitroIndustrializationInterventionInvestigational DrugsInvestigational New DrugsLaboratory ResearchLeadLess-Developed CountriesLess-Developed NationsLive-attenuated VaccineMilitaryMilitary PersonnelMissionModern ManModificationNIAIDNational Institute of Allergy and Infectious DiseaseOrganismPatternPb elementPeople at riskPerformancePersons at riskPhase 1 Clinical TrialsPhase 2 Clinical TrialsPhase I Clinical TrialsPhase II Clinical TrialsPlasmidsPopulationPopulations at RiskPrincipal InvestigatorProceduresProcessProductionResearch InstituteS flexneriS sonneiS. flexneriS. sonneiSafetySeriesShigellaShigella VaccinesShigella flexneriShigella sonneiTarget PopulationsTestingThird-World CountriesThird-World NationsToxinTranslatingUnder-Developed CountriesUnder-Developed NationsVaccine ProductionVaccinesVialVial deviceVirulenceVisitVulnerable PopulationsWorkanti-microbial resistantattenuateattenuatesbiologicsbiopharmaceuticalbiotherapeutic agentburden of diseaseburden of illnesscell bankclinical testcolonization factor antigensconsultationdeploy vaccinesdevelop a vaccinedevelop vaccinesdeveloping countrydeveloping nationdevelopment of a vaccinedevelopmentaldiarrheal diseasediarrheal illnessdisease burdendistribute vaccinesdrug lot productionenteral pathogenenteric pathogenenteropathogenenterotoxigenic E colienterotoxigenic E. colienterotoxigenic E.colienterotoxigenic Escherichia coliexcretionexperienceheavy metal Pbheavy metal leadhost responseimmune response to vaccinationimmune response to vaccinesimmune system responseimmunogenimmunogenicimmunogenicityimmunoresponsein vivointestinal pathogenintestine pathogenkidslive vaccinelive vaccinesliving systemlot productionmanufacturemilitary populationmodel of animalnovelpathogenphase I protocolphase II protocolpre-clinicalpre-clinical studypreclinicalpreclinical studypreventpreventingproduce vaccinesprogramsprotective efficacyprototyperesearch clinical testingresistance to anti-microbialresistant to antimicrobialscale upsuccessvaccine associated immune responsevaccine candidatevaccine deploymentvaccine developmentvaccine distributionvaccine immune responsevaccine immunogenicityvaccine induced immune responsevaccine roll-outvaccine rolloutvulnerable groupvulnerable individualvulnerable peopleyoungster
Description preview
Program Director/Principal Investigator (Last, First, Middle): Barry, Eileen M.
Project Summary
Shigella and enterotoxigenic Escherichia coli (ETEC) are two of the most important diarrheal pathogens
worldwide, causing significant disease in young children in developing countries and in U.S. travelers, including
military personnel, who visit…
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