grant
Adrenomedullin Signaling at the Maternal-Fetal Interface
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Apr 2009Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025ARNTARNT geneAffectAnimal ModelAnimal Models and Related StudiesAryl Hydrocarbon Receptor Nuclear TranslocatorAssayBasic ResearchBasic ScienceBioassayBiological AssayBiological FunctionBiological MarkersBiological ProcessBlood PlasmaBody TissuesCXCRCannot achieve a pregnancyCardiac infarctionCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCells Placenta-TissueCellular FunctionCellular PhysiologyCellular ProcessCellular biologyClinicClinicalCommunicationCytoskeletal ModelingCytoskeletal OrganizationCytoskeletal Organization ProcessCytoskeletal ReorganizationCytotoxic cellDataDefectDifficulty conceivingDioxin Receptor, Nuclear TranslocatorDropsyEPH GestosisEdemaEmbryo DevelopmentEmbryo TransferEmbryogenesisEmbryonic DevelopmentEnvironmental ExposureEnvironmental FactorEnvironmental Risk FactorEpithelial CellsFailureFetal EdemaFetal Growth RestrictionFetal Growth RetardationFetal HydropsFetal healthG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGEM modelGEMM modelGPCRGene ExpressionGeneralized GrowthGenesGeneticGenetically Engineered MouseGestationGestational DiabetesGestational Diabetes MellitusGoalsGrantGrowthHIF-1 Beta GeneHIF-1Beta GeneHIF-1betaHIF1-Beta GeneHIF1BHIF1B GeneHIF1BetaHIF1beta GeneHeartHeart VascularHumanHydropsHydrops FetalisHypoxiaHypoxia-Inducible Factor 1 Beta GeneHypoxia-Inducible Factor 1, Beta subunitHypoxicIUGRImageIn VitroInfertilityInnate ImmunityIntracellular Communication and SignalingIntrauterine Growth RetardationK lymphocyteKnowledgeLaboratoriesLactoferrinLactotransferrinLymphaticLymphatic Endothelial CellsMaternal HealthMaternal-Fetal ExchangeMetabolicMiceMice MammalsMiscarriageModern ManMurineMusMyocardial InfarctMyocardial InfarctionNK CellsNative ImmunityNatural ImmunityNatural Killer CellsNon-Specific ImmunityNonspecific ImmunityNormal PlacentomaNuclear Translocator Gene Dioxin ReceptorOrganoidsOxygen DeficiencyPathway interactionsPeptide Hormone GenePeptide Signal SequencesPeptidesPhenotypePhysiologicPhysiologicalPlacentaPlacenta DiseasesPlacenta DisordersPlacenta Embryonic TissuePlacental DevelopmentPlacental DiseasesPlacentationPlacentomePlasmaPlasma SerumPositionPositioning AttributePre-EclampsiaPreeclampsiaPregnancyPregnancy ComplicationsPregnancy OutcomePregnancy ToxemiasPregnancy-Induced DiabetesProcessPrognostic MarkerProgress ReportsProteinsProteinuria-Edema-Hypertension GestosisReceptor ProteinReceptor SignalingReporterReproductive MedicineReticuloendothelial System, Serum, PlasmaRiboTagRiskRoleSeptic ShockSignal PeptideSignal SequencesSignal TransductionSignal Transduction SystemsSignalingSpiral ArterySpiral Artery of the EndometriumSpontaneous abortionStressStructureSubcellular ProcessSwellingTANGOTestingTherapeuticTissue GrowthTissuesTranscription ActivationTranscriptional ActivationTransplacental ExposureUterusWorkadrenomedullinadrenomedullin receptorangiogenesisarterial remodelingbench bed sidebench bedsidebench to bed sidebench to bedsidebench to clinicbench to clinical practicebio-markersbiologic markerbiological signal transductionbiomarkercardiac infarctcardioprotectantcardioprotectioncardioprotectivecell biologycellular targetingcigarette smokecigarette smoke exposurecigarette smokingcigarette usecirculatory systemclinical diagnosticscomplications during pregnancycoronary attackcoronary infarctcoronary infarctiondiagnostic biomarkerdiagnostic markerdiagnostic tooldosageearly pregnancy lossembryo transplantationenvironmental riskexposure to cigarette smokefertility cessationfertility improvementfertility lossfetalgenetically engineered mouse modelgenetically engineered murine modelhealthy pregnancyheart attackheart infarctheart infarctionimagingimmune healthimmune system healthimpaired fetal growthimplantationimprove fertilityin vivoincrease fertilityinfertileinnovative technologiesinterestintra-uterine growth restrictionintra-uterine growth retardationintrauterine growth restrictionloss of function mutationlymphatic developmentlymphatic formationmaternal-fetal interfacemedical diagnosticmimicrymodel of animalmouse modelmurine modelnovelontogenypathwaypeptide hormonepharmacologicplacental disorderspre-eclampticpregnancy diabetespregnancy toxemia/hypertensionpregnancy-related complicationsprenatal growth disorderprimary infertilityprognostic biomarkerprognostic indicatorprotective effectprotein signal sequencereceptorreproductivereproductive outcomereproductive successsocial rolespatial and temporalspatial temporalspatial temporal imagingspatial temporal mappingspatiotemporalspatiotemporal imagingspatiotemporal mappingsubfertilitytherapeutic targettraffickingwomb
Description preview
Project Abstract
Adrenomedullin (AM) is a multifunctional peptide that is involved in a variety of biological
processes, including embryonic development, angiogenesis, cardio-protection, and innate
immunity. Maternal plasma levels of AM rise substantially during a normal pregnancy, but
abnormally low levels are often associated with a variety of…
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