grant
Adrenergic transmission properties and implication
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 1 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AD dementiaASDAdrenalineAdrenergic AgentsAdrenergic DrugsAdrenergic ReceptorAdrenergicsAdrenoceptorsAlgorithmic AnalysesAlgorithmic AnalysisAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnalyses of AlgorithmsAnalysis of AlgorithmsArousalAttentionAttentional deficitAutismAutistic DisorderBehaviorBiological FunctionBiological ProcessBody TissuesBrainBrain Nervous SystemCNS Nervous SystemCardiovascular DiseasesCell Communication and SignalingCell NucleusCell SignalingCentral Nervous SystemClinicalCognitionComplexCouplingDataDepressive SyndromesDepressive disorderDiffusionEarly Infantile AutismEncephalonEngineeringEpinephrineEpinephrine ReceptorsEventFamilyFutureG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGoldGreen Fluorescent ProteinsHealthHeartHumanImage AnalysesImage AnalysisIndividualInfantile AutismIntracellular Communication and SignalingInvestigationKanner's SyndromeLevarterenolLevonorepinephrineLinkLocus CoeruleusMental disordersMental health disordersMiceMice MammalsMicroscopicModern ManMonitorMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve Transmitter SubstancesNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeuraxisNeurocyteNeurologic DisordersNeurological DisordersNeuronal TransmissionNeuronsNeurotransmittersNoradrenalineNorepinephrineNucleusNucleus Pigmentosus PontisOncogenesisOrganOrganism-Level ProcessOrganismal ProcessOutputPancreasPancreaticParalysis AgitansParkinsonParkinson DiseasePathologicPerformancePeripheralPeripheral Nervous SystemPhysiologicPhysiologic ProcessesPhysiologicalPhysiological ProcessesPlayPonsPons CerebelliPons VaroliiPontinePontine structurePreparationPrimary ParkinsonismPrimary Senile Degenerative DementiaProbabilityPropertyPsychiatric DiseasePsychiatric DisorderReceptor ActivationRegulationResearchRoleSchemeSchizophreniaSchizophrenic DisordersSensorySignal TransductionSignal Transduction SystemsSignalingSiteSleepSleep DisordersSpleenSpleen Reticuloendothelial SystemSynapsesSynapticTestingTherapeutic EpinephrineTissuesTransmissionVisualizationWoodWood materialadenoreceptorattentive deficitautism spectral disorderautism spectrum disorderautistic spectrum disorderaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionblue nucleuscardiovascular disordercognitive functiondementia praecoxdiffuseddiffusesdiffusingdiffusionsexperimentexperimental researchexperimental studyexperimentsglia signalingglial signalinghigh definitionhigh-resolutionhypoimmunityimage evaluationimage interpretationimmune deficiencyimmunodeficiencyimprovedlocus ceruleus structuremental illnessmonoaminenerve signalingneural signalingneurological diseaseneuronalneuronal signalingneurotransmissionnovelpreparationsprimary degenerative dementiapsychiatric illnesspsychological disorderschizophrenicsenile dementia of the Alzheimer typesensorsleep diseasessleep dysfunctionsleep illnesssleep problemsocial rolesuper high resolutionsuperresolutionsynapsetooltransmission processtumorigenesisultra high resolutionultra resolutionultrafine resolution
Description preview
PROJECT SUMMARY
Norepinephrine (NE) and epinephrine (Epi) have been implicated in complex cognitive functions,
such as sensory processing, sleep-wake/arousal state transition and attention, in the brain, and other
biological processes in various tissues and organs, including the heart, pancreas and spleen.
Dysregulation of adrenergic transmission…
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