grant
Adipose FHL1 in energy homeostasis
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 6 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY202515 year old15 years of ageAdipocytesAdipose CellAdipose tissueAgreementAmino Acid SubstitutionAnimal ModelAnimal Models and Related StudiesApplications GrantsAttentionAttenuatedAutoregulationBasal Transcription FactorBasal transcription factor genesBiochemistryBiological ChemistryBiological FunctionBiological ProcessBiologyBypassCRR DomainCardiomyopathiesCase StudyCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell Growth/Cell CycleCell SignalingCell modelCellsCellular biologyCellular modelCompensationCysteine Rich RegionDNA Molecular BiologyDRALDataDevelopmentDysfunctionElementsEnergy ExpenditureEnergy MetabolismEnzyme GeneEnzymesExhibitsFHL1FHL1 geneFHL1BFHL2FHL2 geneFLH1AFat CellsFatty TissueFibroblastsFour and a Half LIM Domains 2Four and a half LIM domains 1Functional disorderGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGoalsGrant ProposalsHigh Fat DietHomeostasisHumanHypertrophyImpairmentIn VitroIn vivo analysisIncidenceIntermediary MetabolismIntracellular Communication and SignalingInvestigationInvestigatorsIsoformsKO miceKYO-TKnock-outKnock-out MiceKnockoutKnockout MiceL-SerineL-TryptophanLIM DomainLIM protein SLIMMERLevotryptophanLinkLipocytesLuciferase ImmunologicLuciferasesMGC111107Mature LipocyteMature fat cellMediatingMediatorMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMiceMice MammalsMitotic Cell CycleModern ManMolecularMolecular BiologyMurineMusMuscleMuscle TissueMuscular DystrophiesMyocardial DiseasesMyocardial DisorderMyocardiopathiesMyocardiumMyodystrophicaMyodystrophyN-terminalNH2-terminalNull MouseObesityPathogenesisPathway interactionsPatientsPhenotypePhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPositionPositioning AttributePrincipal InvestigatorProtein FamilyProtein IsoformsProteinsRegulationReportingResearchResearch PersonnelResearchersResistanceRoleSLIM1SLIM3SerineSignal TransductionSignal Transduction SystemsSignalingSkeletal MuscleSpinal ColumnSpineThesaurismosisTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTryptophanVertebral columnVoluntary MuscleXMPMAadipocyte developmentadipocyte differentiationadipocytokinesadipogenesisadipokinesadiposeadiposityage 15 yearsattenuateattenuatesbA535K18.1backbonebiological signal transductionblood glucose regulationboyscardiac musclecase reportcell biologycellular differentiationcorpulencedevelopmentaldiet-associated obesitydiet-induced obesitydiet-related obesityelderly patientenergy balanceexperimentexperimental researchexperimental studyexperimentsfat metabolismfifteen year oldfifteen years of ageglucose controlglucose homeostasisglucose metabolismglucose regulationheart musclein vivoin vivo evaluationin vivo testinginsightinsulin sensitivityknock-downknockdownlipid biosynthesislipid metabolismlipogenesisloss of functionmembermetabolic phenotypemetabolism disordermetabotypemodel of animalmouse modelmurine modelmuscle dystrophymuscularmyocardium diseasemyocardium disordernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approacholder patientoverexpressoverexpressionparalogparalogous genepathophysiologypathwaypostnatalprotein protein interactionresistantsocial rolesubcutaneoussubdermaltranscription factortransplant modelwhite adipose tissueyellow adipose tissue
Description preview
SUMMARY
Tremendous advances have been made in the study of adipose biology but there are gaps in our understanding
of adipose development and functions. The long-term goal of our research is to understand how adipose tissues
regulate whole-body energy metabolism, insulin sensitivity and glucose homeostasis. To achieve these goals,
we have…
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