grant
Adipokines as novel therapy to promote functional recovery after experimental traumatic brain injury
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 30 May 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2026ACRP30 proteinAD dementiaAction PotentialsAcuteAgonistAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmentiaAmmon HornAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApoptoticAreaArteriosclerotic DementiaAttenuatedBehavioralBindingBlood VesselsBlood monocyteBrainBrain Nervous SystemBrain TraumaBrain VascularBrain Vascular TraumaCandidate Disease GeneCandidate GeneCell BodyCell Communication and SignalingCell SignalingCellsCerebrovascular CirculationCerebrovascular TraumaCerebrovascular systemChronicClinicalCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCornu AmmonisDWI (diffusion weighted imaging)DWI-MRIDataDementiaDevelopmentDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDisablingDisturbance in cognitionDrugsDysfunctionEconomic BurdenEncephalonEndocrine Gland SecretionEndothelial CellsEndotheliumFiberFosteringFunctional disorderGenesGoalsGrowth AgentsGrowth FactorGrowth HormoneGrowth Hormone 1Growth SubstancesHippocampusHistologicHistologicallyHormonesHortega cellHuman Growth HormoneImpaired cognitionImpairmentIn vivo analysisInflammationInflammatoryInjuryIntracellular Communication and SignalingKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLong-Term PotentiationMacrophageMarrow monocyteMechanicsMediatingMedicationMemory LossMiceMice MammalsMicrogliaMissionModelingMolecularMolecular InteractionMurineMusMyelinMφNatural regenerationNerve CellsNerve DegenerationNerve UnitNervous System PhysiologyNeural CellNeurocyteNeurologic functionNeurologic outcomeNeurological functionNeurological outcomeNeuron DegenerationNeuronsNull MouseOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOutcomePPAR alphaPPAR-αPPARalphaPPARαPathologyPathway interactionsPatientsPeripheralPeroxisome Proliferator-Activated Receptor alphaPeroxisome Proliferator-Activated Receptor αPharmaceutical PreparationsPhenotypePhysiopathologyPituitary Growth HormonePrimary Senile Degenerative DementiaPropertyProteins Growth FactorsPyramidal neuronQOL improvementReceptor ActivationReceptor ProteinRecoveryRecovery of FunctionRegenerationReportingResolutionRiskRoleSeveritiesSignal TransductionSignal Transduction SystemsSignalingSiteSomatotropinSyndromeTBI recoveryTestingTherapeuticTherapeutic InterventionTranslationsTraumatic Brain InjuryTraumatic Brain Injury recoveryVascular Brain InjuryVascular DementiaVascular blood supplyWorkadipocyte complement-related protein 30-kDaadipocyte, C1q and collagen domain containing proteinadipocytokinesadipokinesadiponectinangiogenesisapM-1 proteinapM1 (adipose-specific) proteinattenuateattenuatesaxon damageaxon injuryaxonal damageaxonal injurybehavior testbehavioral testbiological signal transductionblood damageblood flow in brainblood supplyblood vessels in the brainbrain blood circulationbrain blood flowbrain blood vesselsbrain endothelial cellbrain microvascular endothelial cellbrain repairbrain vascular endothelial cellbrain vasculaturecardiac disease induced cognitive impairmentcell typecerebral blood flowcerebral blood vesselcerebral circulationcerebral endothelial cellcerebral microvascular endothelial cellcerebral vascularcerebral vascular endothelial cellcerebral vascular injurycerebral vasculaturecerebro-vascularcerebrocirculationcerebrovascularcerebrovascular blood flowcerebrovascular contribution to cognitive impairment and dementiacerebrovascular contributions to dementiacerebrovascular injurycerebrovascular vesselscerebrovasculatureclinical riskcognitive defectscognitive disabilitycognitive dysfunctioncognitive losscognitively disabledconditional knock-outconditional knockoutcontrolled cortical impactcritical injurydMRIdevastating injurydevelopmentaldiffusion tensor imagingdisabilitydrug/agentfunctional recoveryfunctional restorationgain of functiongitter cellgray matterhGHhippocampalhippocampal pyramidal neuronimprovedimprovements in QOLimprovements in quality of lifein vivo evaluationin vivo testinginjuriesintervention therapyintraperitonealischemia injuryischemic injurylong-term recoveryloss of functionmechanicmechanicalmemory declinemesogliamicroglial cellmicrogliocytemitochondrial dysfunctionmonocytemouse modelmurine modelnerve cell deathnerve cell lossnervous system functionneuralneural degenerationneural inflammationneuro-vascular damageneuro-vascular injuryneuro-vascular unitneurodegenerationneurodegenerativeneuroinflammationneuroinflammatoryneurological degenerationneurological recoveryneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuroprotectionneuroprotectiveneurovascular damageneurovascular injuryneurovascular unitnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathophysiologypathwayperivascular glial cellpreservationpreventpreventingprimary degenerative dementiaquality of life improvementre-myelinatere-myelinationreceptorrecovery after TBIrecovery after traumatic brain injuryregenerateregenerativeremyelinateremyelinationrepairrepairedresolutionsrestorationrestore functionrestore functionalityrestore lost functionscRNA sequencingscRNA-seqsenile dementia of the Alzheimer typesevere injuryshear stresssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall moleculesocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicssomatotropic hormonesubstantia albasubstantia griseatissue repairtooltranscriptomicstranslationtraumatic brain damagevascularvascular cognitive impairment and dementiavascular cognitive impairment/dementiavascular contribution to impairment or dementiavascular contributions in dementiavascular contributions to cognition/dementiavascular contributions to cognitive decline and dementiavascular contributions to cognitive impairment and dementiavascular contributions to dementiavascular related dementiavascular supplywhite matter
Description preview
Traumatic brain injury (TBI) can elicit cognitive disabilities due to mechanical shearing of the vascular supply, damage of the neurovascular unit, and secondary cascades of endothelial and microglial inflammation, and neurodegeneration. TBI increases the risk of clinical dementia, including Vascular Cognitive Impairment and Dementia (VCID), by…
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