grant
Adipocytes and inflammation in the cutaneous leishmaniasis outcome
Organization FEDERAL UNIVERSITY OF BAHIALocation SALVADOR, BRAZILPosted 20 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025(TNF)-α24-DehydrocholesterolACRP30 proteinAdipocytesAdipose CellAdipose tissueAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAreaAsthmaB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Basal Transcription FactorBasal transcription factor genesBeta Proprotein Interleukin 1Binding ProteinsBody TissuesBronchial AsthmaCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCRG-2CXCL10CXCL10 geneCXCL9CXCL9 geneCachectinCardiovascular DiseasesCell BodyCell Communication and SignalingCell SignalingCellsCellular Immune FunctionChemotactic CytokinesCholesterol HomeostasisClinicalCoriumCutaneous LeishmaniasisCutisCytotoxic cellDataDemosterolDermisDesmosterolDevelopmentDiseaseDisorderDrugsElementsEndocrine Gland SecretionFIZZ3FailureFat CellsFatty Acid Metabolism PathwayFatty TissueFound in Inflammatory Zone 3Gene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGeographic AreaGeographic LocationsGeographic RegionGeographical LocationHPGFHepatocyte-Stimulating FactorHomologous Chemotactic CytokinesHormonesHumigHybridoma Growth FactorHypodermisIFI10IFN-beta 2IFNB2IL-1 betaIL-1 βIL-1-bIL-1βIL-6IL1-BetaIL1-βIL1B ProteinIL1F2IL1βIL6 ProteinINP10IP-10ImmuneImmune responseImmunesIndividualInfectionInflammationInflammatoryInflammatory InfiltrateInflammatory ResponseIntercrinesInterleukin 1betaInterleukin-1 betaInterleukin-1βInterleukin-6Intracellular Communication and SignalingInvadedK lymphocyteLeannessLeishmania (Viannia) braziliensisLeishmania brasiliensisLeishmania braziliensisLeishmania viannia brasiliensisLeptinLesionLeucocytic infiltrateLigand Binding ProteinLigand Binding Protein GeneLigandsLipidsLipocytesLiver X ReceptorLymphatic cellLymphocyteLymphocyticLytotoxicityMGI-2MIG GeneMOB-1MacrophageMacrophage-Derived TNFMature LipocyteMature fat cellMediatingMedicationMeglumineMethylglucamineMonocyte-Derived TNFMononuclearMorbidityMorbidity - disease rateMyeloid Differentiation-Inducing ProteinMφN-3 polyunsaturated fatty acidNK CellsNatural Killer CellsOb Gene ProductOb ProteinObese Gene ProductObese ProteinObesityOmega-3 Fatty AcidsOmega-3 PUFAOmega-3 Polyunsaturated Fatty AcidOmega3OutcomePPAR gammaPPAR-gPPAR-γPPARgammaPPARγParasitesPathway interactionsPatientsPeroxisome Proliferative Activated Receptor GammaPeroxisome Proliferator-Activated Receptor gammaPeroxisome Proliferator-Activated Receptor γPhagocytesPhagocytic CellPharmaceutical PreparationsPhenotypePlasmacytoma Growth FactorPreinterleukin 1 BetaProcessProductionPropertyProtein BindingPsoriasisPublic HealthRETNReactionReceptor ProteinRegional DiseaseRoleSCYB10SCYB9SIS cytokinesSeveritiesSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSiteSkinSkin developmentSterolsSubcutaneous TissueSubcutisSuperficial FasciaT8 CellsT8 LymphocytesTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTela SubcutaneaTherapeuticTherapeutic HormoneThiazolidinedione ReceptorThinnessTimeTissuesTranscription Factor Proto-OncogeneTranscription factor genesTransmissionTumor Necrosis FactorTumor Necrosis Factor-alphaWound Repairadipocyte complement-related protein 30-kDaadipocyte, C1q and collagen domain containing proteinadipocytokinesadipokinesadiponectinadiposeadiposityamebocyteapM-1 proteinapM1 (adipose-specific) proteinbiological signal transductionbound proteincardiovascular disorderchemoattractant cytokinechemokinecholesterol controlcholesterol managementcholesterol metabolismcohortcorpulencecrg-10cutaneous lesionscytokinecytotoxicitydermal leishmaniasisdermal lesiondevelopmentaldisease severitydrug/agentfatty acid metabolismgIP-10geographic sitehealinghost responseimmune functionimmune system responseimmunoresponseinflammatory modulationinterferon beta 2lipidomicslymph cellmanage cholesterolmortalityn-3 Fatty Acidsn-3 PUFAobese patientsomega-3omega-3spathwaypatients with obesityperipheral bloodprogramspsoriasiformpsoriaticreceptorresistance to therapyresistant to therapyresistinresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskin lesionskin organogenesisskin ulcersocial rolesubdermal tissuetherapeutic resistancetherapeutic targettherapy resistanttissue repairtranscription factortransmission processtreatment resistanceulcerative woundswhite adipose tissuewound healingwound recoverywound resolutionyellow adipose tissue
Description preview
Summary
Leishmania braziliensis infection may cause a high spectrum of clinical manifestation, including the more
prevalent form, cutaneous leishmaniasis (CL). Inflammatory response is a hallmark of CL and high levels of
TNF, IL-1b, and cytotoxicity are associated with skin ulcer development in these individuals. Our preliminary
data show that…
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