grant
Acylcarnitine Metabolism in Ovarian Cancer Chemoresistance
Organization WISTAR INSTITUTELocation PHILADELPHIA, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2026AblationAcetyl CarnitineAcetyl CoAAcetyl Coenzyme AAcetylationAcetylcarnitineAtlasesAutomobile DrivingBreast CancerCDDPCancer PatientCancersCarnitineChemoresistanceCis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumClinicalCysplatynaDNA DamageDNA Damage RepairDNA InjuryDNA RepairDataDichlorodiammineplatinumDietDietary InterventionDiseaseDisorderDrug TherapyEnzyme GeneEnzymesEpithelial ovarian cancerFemale Reproductive CancerFutureGeneticGoalsGynecologic CancerGynecological CancerHeterograftHeterologous TransplantationHistone AcetylationIntermediary MetabolismInterventionKnowledgeMalignant Breast NeoplasmMalignant Female Reproductive System NeoplasmMalignant Gynecologic NeoplasmMalignant Gynecologic TumorMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the Female Reproductive SystemMalignant Tumor of the OvaryMalignant neoplasm of ovaryMalignant neoplasm of prostateMalignant prostatic tumorMapsMediatingMetabolicMetabolic PathwayMetabolic ProcessesMetabolismModelingMolecularNGS MethodNGS systemNuclearNutrition InterventionsNutritional InterventionsOvarian Serous AdenocarcinomaOvarian Serous CarcinomaOvary CancerPARP InhibitorPARP-1 inhibitorPARPiPathway interactionsPatientsPeyrone's ChloridePeyrone's SaltPharmacological TreatmentPharmacotherapyPlatinumPlatinum BlackPlatinum DiamminodichloridePoly(ADP-ribose) Polymerase InhibitorPoly(ADP-ribose) polymerase 1 inhibitorPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProstate CAProstate CancerProstate malignancyProtein ModificationPt elementResearchResistanceS-acetate Coenzyme ASerous Adenocarcinoma of the OvarySerous Carcinoma of the OvarySiteSourceTestingTherapeuticUnscheduled DNA SynthesisWorkXenograftXenograft procedureXenotransplantationacyl groupacylcarnitinechemoresistantchemotherapy resistancechemotherapy resistantcis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumdiet interventiondietarydietsdrivingdrug interventiondrug treatmentgynecologic malignancygynecological malignancyhomologous recombinationimprovedinsightknock-downknockdownmalignancymalignant breast tumormouse modelmurine modelneoplasm/cancernew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnext gen sequencingnext generation sequencingnextgen sequencingnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetovarian cancerpathwaypharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsrepairrepairedresistantresponsestandard of caretherapeutic outcometherapy outcometraffickingtumoruptakexeno-transplantxeno-transplantation
Description preview
PROJECT SUMMARY ABSTRACT
High-grade serous ovarian carcinoma (HGSOC) is the most prevalent histosubtype of epithelial ovarian cancer.
Therapy for HGSOC relies on DNA damaging agents, with a high percentage of cancers having de novo or
acquired chemoresistance due in part to homologous recombination (HR) proficiency. Our preliminary data has…
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