grant
Activity-dependent cell survival in the adult somatosensory dorsal horn: Implications for sensorimotor behaviors during aging
Organization SALK INSTITUTE FOR BIOLOGICAL STUDIESLocation La Jolla, UNITED STATESPosted 15 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20262 year old2 years of age21+ years oldAblationAcuteAdultAdult HumanAffectAgeAgingAnatomic SitesAnatomic structuresAnatomyAnimalsApoptosisApoptosis PathwayApoptoticBehaviorCell BodyCell DeathCell FunctionCell PhysiologyCell ProcessCell SurvivalCell ViabilityCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeChronicCutaneousDataDeathDemyelinationsDevelopmentDiabetes MellitusDiseaseDisorderDorsal Horn CellsDorsal Horn NeuronsDorsal Root GangliaDysfunctionElectrophysiologyElectrophysiology (science)ExhibitsFeedbackFunctional disorderGene ExpressionGeneticHindlimbHornsImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpairmentIn Situ Nick-End LabelingIn VitroInjuryInvestigationItchingLabelLocomotionMerkel CellsMerkel's ReceptorMethodsMiceMice MammalsMolecularMolecular FingerprintingMolecular ProfilingMonitorMotorMotor CellMotor NeuronsMotor SkillsMurineMusNerve CellsNerve UnitNervous SystemNeural CellNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNeurophysiology / ElectrophysiologyOlder PopulationOrganPNS DiseasesPainPainfulPathway interactionsPerformancePeripheralPeripheral Nerve DiseasesPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPhysiopathologyPopulationPopulation AnalysisPosterior Horn CellsPosterior Horn NeuronsPredispositionProcessProgrammed Cell DeathPruritic DisorderPruritisPruritusRabies mappingRabies trans synaptic tracingRabies virus mediated mappingReceptor ProteinReporterResistanceRoleSensorySkinSpinalSpinal GangliaStaining methodStainsSubcellular ProcessSupporting CellSurfaceSusceptibilitySynapsesSynapticTUNELTactileTamoxifenTestingTherapeuticTouchTouch sensationTransgenic MiceTransmissionaberrant agingabnormal agingadult animaladult youthadulthoodage 2age 2 yearsage associatedage correlatedage dependentage linkedage relatedage specificagedaged 2 yearsaged animalaged animalsaged miceaged mouseaged two yearsagesanimal old agechemotherapydemyelinatedevelopmentaldiabetesdorsal horndorsal root gangliondysfunctional age related changedysfunctional agingelderly animalelderly miceelectrophysiologicalexperimentexperimental researchexperimental studyexperimentshigh definitionhigh-resolutionimmunohistochemical biomarkersimmunohistochemical markersimpaired aginginjuriesitch sensationlife spanlifespanlocomotor deficitmaladaptive agingmature animalmolecular profilemolecular signaturemotoneuronmotor abilitymotor behaviormotor recoverynatural agingnecrocytosisnerve cell deathnerve cell lossneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal lossneuronal patterningneuronal survivalnormal agingnormative agingnovelold animalsold miceolder groupsolder individualsolder personpathological age related changespathological agingpathophysiologypathwaypreventpreventingrabies based mappingrabies based retrograde mappingrabies circuit tracingrabies mediated retrograde monosynaptic tracingrabies retrograde tracingrabies tracerrabies tracingrabies viral tracingrabies virus mediated circuit mappingrabies virus monosynaptic circuit tracingrabies virus monosynaptic tracingrabies virus neurotracerrabies virus retrograde tracingrabies virus tracingreceptorresistantskillssocial rolesomatosensoryspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssynapsetactile sensationterminal nick end labelingtooltracing with rabiestranscriptomicstransmission processtreatment strategytwo year oldtwo years of ageyoung adultyoung adult ageyoung adulthood
Description preview
Project Summary/Abstract
The somatosensory dorsal horn comprises an array of neuronal populations that receive sensory information
from the skin. In recent years, the development of transcriptomic and intersectional genetic tools has allowed
the characterization of these populations in young adult animals with respect to their distinct molecular…
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