grant
Activity-based protein profiling of gut microbiota-associated bile acid metabolism
NIHUS FederalResearch GrantFY2025AddressAffectAlimentary CanalAllergyBacteriaBacterial Gene ProductsBacterial Gene ProteinsBacterial ProteinsBile AcidsBiochemicalBiochemical PathwayBiochemistryBiological ChemistryBiotransformationBody TissuesCancersCell BodyCellsChemicalsComplexDigestive TractDiseaseDisorderEnzyme GeneEnzymesFunctional MetagenomicsGI TractGI colonizationGI microbiomeGI microbiotaGastrointestinal TractGastrointestinal microbiotaGastrointestinal tract structureGenesGut EpitheliumHealthHumanHydrolaseHydrolase Family GeneHydrolase GeneImageImmunityIndividualInflammationInflammatory Bowel DiseasesInflammatory Bowel DisorderIntermediary MetabolismIntestinalIntestinesMalignant NeoplasmsMalignant TumorMetabolicMetabolic BiotransformationMetabolic NetworksMetabolic PathwayMetabolic ProcessesMetabolic syndromeMetabolismMetagenomicsMiceMice MammalsMicrobeModern ManMurineMusPathologyPhysiologyPlayProductionProteinsReportingResearchRoleSystemTechnologyTissuesVisualizationWorkactivity-based protein profilingalimentary tractbacteria in the gutbacteria pathogenbacterial pathogenbile acid metabolismbile metabolismbile saltsbowelcommensal bacteriacommensal bacterial speciesdigestive canaldigestive tract microbiomeenteric microbial communityenteric microbiomeenteric microbiotaenzyme activityenzyme pathwaygastrointestinal epitheliumgastrointestinal microbial floragastrointestinal microbiomegastrointestinal tract colonizationgut bacteriagut colonizationgut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomeimaginginflammatory disease of the intestineinflammatory disorder of the intestineintestinal autoinflammationintestinal biomeintestinal colonizationintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloramalignancymicrobialmicrobiomemicroorganismneoplasm/cancerpathogenic bacteriaprophylacticsmall moleculesocial roletherapeutic agent developmenttherapeutic developmenttool
Description preview
Project Summary/Abstract
The human intestines are colonized by trillions of microorganisms, termed the gut microbiota, which are thought
to rival the number of our own cells. Together, these microbes metabolize small molecules within the intestinal
lumen through the activities of bacterial enzymes that carry out biochemical transformations.…
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