grant
Activation of Proto-Oncogenes by Chromosomal Translocation
Organization DIVISION OF CLINICAL SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY202598 kD Nucleoporin98-kD Gene NucleoporinADIR2AneuploidAneuploidyAnimal ModelAnimal Models and Related StudiesAnimalsAntioncogene Protein p53AssayBioassayBiological AssayBlood Precursor CellCancersCell BodyCell LineCellLineCellsCellular OncogeneCellular Tumor Antigen P53Chromosomal dislocationChromosomal translocationChromosomesClinicalCollaborationsDevelopmentGLFG-Repeat Containing NucleoporinGenesGeneticGenetic TranslocationHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoieticHematopoietic CancerHematopoietic Progenitor CellsHematopoietic stem cellsLesionLinkMalignantMalignant - descriptorMalignant Hematologic NeoplasmMalignant NeoplasmsMalignant TumorMiceMice MammalsMurineMusMutateNUP196NUP96 GeneNUP98NUP98 geneNUP98-NUP96 PrecursorNeoplasmsNodalNuclear Pore Complex Protein NUP98Nucleoporin 98kDNucleoporin NUP98OncogenicOncoprotein p53P53Phosphoprotein P53Phosphoprotein pp53Point MutationPopulationProcessProtein TP53Proto-OncogenesPublishingRecurrenceRecurrentStrains Cell LinesTP53TP53 geneTRP53TestingTimeTransgenesTranslocation BreakpointTumor Protein p53Tumor Protein p53 GeneYeastsblood cell progenitorblood progenitorblood stem cellblood-forming stem cellc-ONCchromosomal missegregationchromosome dislocationchromosome missegregationchromosome translocationcultured cell linedevelopmentalearly onsetexperimentexperimental researchexperimental studyexperimentsfusion genegene cloninghematopoietic progenitorhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellin vivoleukemialeukemia initiating cellmalignancymodel of animalneoplasianeoplasm/cancerneoplastic growthnovelnuclear pore complex protein 98overexpressoverexpressionp53 Antigenp53 Genesp53 Tumor Suppressorprecancerprecancerouspremalignantprogenitor cell poolprogenitor cell populationprogenitor poolprogenitor populationprotein p53protooncogenestem and progenitor cell populationstem cell poolstem cell populationtransgene
Description preview
CENPA overexpression has been linked to several malignancies, and CENPA overexpression in yeast and cultured cell lines leads to chromosomal mis-segregation and subsequent aneuploidy. In collaboration with Dr. Munira Basrai of the Genetics branch, we generated mice that overexpress CENPA in the hematopoietic compartment to determine if the…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click