grant
Accessing Carbon-based S(VI) compounds via Sulfur-Fluorine (SuFEx) Exchange Reactions
NIHUS FederalResearch GrantFY2025AcidsAddressAlkanesulfonatesAlkyl SulfonatesAlkylsulfonate CompoundAminesBacterial InfectionsCalciumCancersCarbonCardiovascular DiseasesCatalysisChemistryComplexCouplingDataDecarboxylationDevelopmentDiseaseDisorderDrug PrescribingDrug PrescriptionsDrug TargetingEnvironmentEstersF elementFluoridesFluorineFundingGenerationsGrantInflammatoryKineticsLi+ elementLibrariesLithiumMalignant NeoplasmsMalignant TumorMediatingMedicinal ChemistryMetalsMethodsModelingNMR SpectrometerNMR SpectroscopyNitrogenOxidation-ReductionPathway interactionsPharmaceutic ChemistryPharmaceutical AgentPharmaceutical ChemistryPharmaceuticalsPharmacologic SubstancePharmacological SubstancePublic HealthReactionReagentRedoxResearchResistanceRoleS elementSaltsSodium ChlorideStructureSulfateSulfonamidesSulfone Anti-Infective AgentSulfonesSulfurSulfur CompoundsSynthesis ChemistrySynthetic ChemistryTestingTherapeuticWorkaminebacteria infectionbacterial diseasebasebasescardiovascular disordercatalystchelationcollegecollegiatecomputational studiescomputer studiescostdesigndesigningdevelopmentaldrug discoveryenolateinnovateinnovationinnovativeinsightintermolecular interactionmalignancymedication prescriptionneoplasm/cancernovelnuclear magnetic resonance spectroscopyorganic baseoxidation reduction reactionpathwaypharmaceuticalprescribed medicationpreventpreventingresistantsaltsocial rolestereochemistrysulfonatetherapeutic targetundergradundergraduateundergraduate student
Description preview
S(VI)-based compounds are a critical class of organic molecules with biomedical applications
against inflammatory disorders, cancer, and bacterial infections. Approaches to making
these carbon-based sulfur(VI) compounds are limited by the commercial availability of starting
materials and harsh reactions preventing late-stage functionalization.…
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