grant
Accelerator for the rapid development of countermeasures targeting drug resistant fungal pathogens
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025A fumigatusA. fumigatusAIDS VirusAcademiaAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAdvanced DevelopmentAffectAnimal ModelAnimal Models and Related StudiesAntibodiesAspergillus fumigatusAspergillus resistanceAzole resistanceAzole resistantBiogenesisBiological AgentBiological ProductsBloodBlood Reticuloendothelial SystemC aurisC. aurisC. glabrataCOVID-19CV-19CancersCandidaCandida aurisCandida glabrataCandida resistanceCandida resistant isolateCell WallChronicClinicalCollaborationsCoronavirus Infectious Disease 2019Death RateDedicationsDetectionDevelopmentDiabetes MellitusDiagnosisDiagnosticDiseaseDisorderDrug TargetingDrug TherapyDrug resistanceDrugsEffectivenessEnsureEnzyme GeneEnzymesFDA approvedFungal Drug ResistanceFungus DiseasesFungus drug resistantGPI Membrane AnchorsGlycoinositol Phospholipid Membrane AnchorGlycosyl-Phosphatidylinositol Membrane Protein AnchorsGlycosylphosphatidylinositol AnchorsGoalsGrafting ProcedureGrippeHIVHuman Immunodeficiency VirusesImmune mediated therapyImmune systemImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunologically Directed TherapyImmunosuppressed HostImmunotherapyIndividualIndustryInfectionInfluenzaInvestigational DrugsInvestigational New DrugsKnowledgeLAV-HTLV-IIILeadLifeLymphadenopathy-Associated VirusM tuberculosis infectionM. tb infectionM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMalignant NeoplasmsMalignant TumorMarketingMedicalMedicationMedicinal ChemistryMicrobiologyMissionMoniliaMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMycologyMycosesOrgan TransplantationOrgan TransplantsOrigin of LifeOutcomePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPb elementPharmaceutic ChemistryPharmaceutical ChemistryPharmaceutical PreparationsPharmacological TreatmentPharmacologyPharmacotherapyProcessProductivityPublic HealthRapid diagnosticsRecordsResearch ResourcesResistanceResistant candidaResourcesRespiration DisordersRespiratory DisorderScienceStandardizationTB infectionThe science of MycologyTherapeuticTherapeutic FungicidesTimeTorulopsis glabrataTranslational ResearchTranslational ScienceTransplantationTuberculosisVirus-HIVanti-fungalanti-fungal agentsanti-fungal druganti-fungal drug resistanceanti-fungal drug resistantanti-fungal resistanceanti-fungal resistantbiologicsbiopharmaceuticalbiopharmaceutical companybiopharmaceutical industrybiotherapeutic agentblood infectionbloodstream infectionbreathing disordercombatcompound optimizationcoronavirus disease 2019coronavirus disease-19coronavirus infectious disease-19developmentaldiabetesdiagnostic abilitydiagnostic capabilitydiagnostic developmentdiagnostic platformdiagnostic powerdiagnostic systemdiagnostic tooldiagnostic utilitydiagnostic valuedisseminated TBdisseminated tuberculosisdrug candidatedrug developmentdrug interventiondrug resistantdrug treatmentdrug/agentexperienceformulation optimizationfungal infectionfungal pathogenfungi pathogenfungus drug resistancefungus infectionglucan synthaseheavy metal Pbheavy metal leadimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunosuppressed patientimprovedin vivoin vivo Modelinfection due to Mycobacterium tuberculosisinfection in the bloodinfection of the bloodinnovateinnovationinnovativelead optimizationmalignancymannoproteinsmodel of animalmortalitymortality ratemortality rationeoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyorgan allograftorgan graftorgan xenograftpathogenpathogenic funguspatient oriented outcomespharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspoint of carepoint-of-care diagnosticspre-clinical developmentpreclinical developmentpreventpreventingprogramsrapid detectionresistance among Candidaresistance in Aspergillusresistance in Candidaresistance strainresistance to Drugresistance to anti-fungalresistance to azoleresistantresistant Aspergillusresistant Candida strainsresistant strainresistant to Drugresistant to anti-fungalresistant to azolerespiratoryrespiratory dysfunctionresponsesmall moleculetranslation researchtranslational investigationtransplanttuberculosis infectiontuberculous spondyloarthropathy
Description preview
SUMMARY
Invasive fungal infections pose a significant medical challenge, particularly for individuals with compromised
immune systems or other conditions due to HIV, cancer, organ transplantation, diabetes, chronic respiratory
ailments, tuberculosis, COVID-19, and influenza. Prompt diagnosis and effective antifungal treatment are crucial
for…
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