grant
Accelerated Epithelial Cell Detachment in Progression of Kidney Disease
Organization VETERANS HEALTH ADMINISTRATIONLocation ANN ARBOR, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2030
VANIHUS FederalResearch GrantFY2026AccelerationAdhesivesAdipose tissueAssayBindingBioassayBioinformaticsBiological AssayBiological MarkersBody TissuesBone-Derived Transforming Growth FactorCaringCause of DeathCell Communication and SignalingCell Death SignalingCell Death Signaling ProcessCell Membrane ProteinsCell SignalingCell-Extracellular MatrixCellular MatrixCellular StressCellular Stress ResponseChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicalCo-ImmunoprecipitationsCultured CellsCytoskeletal SystemCytoskeletonDataDiabetes MellitusDiabetic Kidney DiseaseDiabetic NephropathyDiseaseDisease ProgressionDisorderECMEpithelial CellsExhibitsExtracellular MatrixFSGSFamilyFatty TissueFibrosisFocal and Segmental GlomerulosclerosisFocal segmental glomerular sclerosisGeneral PopulationGeneral PublicGenesHealth Care SystemsHumanImmuneImmune infiltratesImmunesIn VitroIncidenceIndividualInjury to KidneyInsulin ResistanceIntegrinsIntegrins Extracellular MatrixInterventionIntervention StrategiesIntracellular Communication and SignalingKidneyKidney DiseasesKidney FailureKidney InsufficiencyKidney Replacement TherapyKidney Urinary SystemLinkLupus GlomerulonephritisLupus NephritisMachine LearningMeasuresMediatingMediatorMessenger RNAMethodsMiceMice MammalsMichiganMilk Growth FactorModelingModern ManMolecularMolecular InteractionMonitorMurineMusNephropathyObesityOutcomePathogenesisPathologicPathway interactionsPatient CarePatient Care DeliveryPatientsPhenotypePhysiciansPlatelet Transforming Growth FactorPrevalenceProtein SecretionProteinsRenal CellRenal DiseaseRenal FailureRenal InsufficiencyRenal Replacement TherapyResearchResearch ResourcesResidualResidual stateResourcesRiskRisk FactorsRoleSTZSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStreptozocinStreptozotocinSupporting CellSystems BiologyTGF BTGF-Beta 1TGF-Beta1TGF-betaTGF-βTGFBTGFB1TGFB1 geneTGFbetaTGFβTestingTherapeuticTissuesTransforming Growth Factor Beta 1Transforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransgenic MiceUnited States Department of Veterans AffairsUnited States Veterans AdministrationUniversitiesUrineVeteransVeterans AdministrationVeterans AffairsVisceral Epithelial CellZanosaradiposeadipositybio-markersbiobankbiologic markerbiological signal transductionbiomarkerbiorepositorycare for patientscare of patientscaring for patientscell stresscell typechronic kidney diseaseclinical applicabilityclinical applicationclinical phenotypecohortcorpulencecostdamage to kidneydensitydiabetesglomerular sclerosisglomerular visceral epithelial cellglomerulosclerosisimmune cell infiltratein vivo Modelindividual patientinsulin resistantinsulin toleranceinterstitialintracellular skeletonkidney biopsykidney cellkidney damagekidney disorderkidney injurymRNAmachine based learningmouse modelmurine modeloverexpressoverexpressionparticipant enrollmentpathwaypatient enrollmentpatient stratificationpodocyteprotein functionrenalrenal biopsyrenal damagerenal disorderrenal epitheliumrenal injuryresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestratified patienttherapeutic targettranscriptomicstransforming growth factor beta1urinarywhite adipose tissueyellow adipose tissue
Description preview
Chronic kidney disease (CKD) is a progressive condition that puts a substantial burden on individuals,
families, and health care systems. CKD is already a leading cause of death world-wide, and the
incidence and prevalence is expected to rise. CKD is about 34% more common in veterans than in the
general population, and U.S. Department of Veterans…
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