grant
Abnormal Extracellular Vesicles and Particles from Human Islets Impact T1D progression
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 21 Aug 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AF-4AF4Alpha CellAntigen PresentationAntigen-Presenting CellsApoptoticBeta CellBindingBiological MarkersBiologyBlood PlasmaBlood VesselsBody FluidsBody TissuesBrittle Diabetes MellitusCell BodyCell CommunicationCell FunctionCell InteractionCell LineCell PhysiologyCell ProcessCell SurvivalCell ViabilityCell membraneCell-to-Cell InteractionCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessCoxsackie VirusesCoxsackievirusCytoplasmic MembraneDNAData BasesDatabasesDeoxyribonucleic AcidDevelopmentDiagnosisDysfunctionEndocrineEndothelial CellsField Flow FractionationFunctional disorderGlucagon CellGlucagon Secreting CellHeterogeneityHumanIDDMImmuneImmunesInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusIslet CellJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusLipid BilayersLipidsMLLT2MLLT2 geneMacrophageMediatingMediatorMembraneMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMethodsMicroRNAsMicrofluidic DeviceMicrofluidic Lab-On-A-ChipMicrofluidic MicrochipsModern ManMolecularMolecular FingerprintingMolecular InteractionMolecular ProfilingMφNon-Polyadenylated RNAOrganOrganoidsOutcomePancreasPancreaticPathogenicityPathologicPatient CarePatient Care DeliveryPatientsPhysiopathologyPlasmaPlasma MembranePlasma SerumProteinsProteomicsRNARNA Gene ProductsReticuloendothelial System, Serum, PlasmaRibonucleic AcidRoleSamplingSliceStrains Cell LinesStressStructureSubcellular ProcessSudden-Onset Diabetes MellitusSurface ProteinsT1 DMT1 diabetesT1DT1DMTechnologyTestingTissuesType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUltracentrifugationVascular blood supplyVascularizationaccessory cellalpha-cellautoimmune reactivityautoreactivitybio-markersbiologic markerbiomarkerblood supplycare for patientscare of patientscaring for patientscell typecultured cell linecytokinedata basedevelopmentaldiabetes pathogenesisexosomeextracellularextracellular vesiclesgain of functionhuman derived pluripotent stem cellhuman pluripotent stem cellinsulin dependent diabetesinsulin dependent diabetes mellitus onsetinsulin dependent type 1isletjuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteslipid bilayer membranemembrane structuremiRNAmicrofluidic chipmolecular profilemolecular signaturemouse modelmurine modelnano particlenano-sized particlenanoparticlenanosized particlenew drug treatmentsnew drugsnew markernew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovel biomarkernovel drug treatmentsnovel drugsnovel markernovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachparticlepathophysiologyplasmalemmapreventpreventingsenescencesenescentsignature moleculesocial rolesuperresolution imagingtype 1 diabetes onsettype I diabetestype one diabetesvascularvascular supplyα-cellβ-cellβ-cellsβCell
Description preview
Abstract.
Extracellular vesicles and particles (EVPs) are a group of heterogeneous nanoparticles that are secreted into
the extracellular milieu by many types of cells. EVPs have emerged as important mediators in cell-to-cell
communications within organs. Recent studies have suggested that EVPs might be involved in β cell-immune
cell interaction…
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