grant
A versatile bimodal QF/QS gene expression system for insect and vertebrate models based on conditional protein self-splicing
Organization TEXAS A&M UNIVERSITY HEALTH SCIENCE CTRLocation COLLEGE STATION, UNITED STATESPosted 9 Feb 2026Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202621+ years oldATP phosphohydrolaseATPaseAbscissionAdenosine TriphosphataseAdultAdult HumanAedesAgeAllelesAllelomorphsAnimalsAnophelesAnopheles GenusAnophelinesBBB crossingBacteriaBacterial Gene ProductsBacterial Gene ProteinsBacterial ProteinsBaker's YeastBasal Transcription FactorBasal transcription factor genesBinding SitesBiologic ModelsBiological FunctionBiological ModelsBiological ProcessBiologyBody TissuesBrachydanio rerioBrewer's YeastC elegansC. elegansC.elegansCRISPRCRISPR/Cas systemCaenorhabditis elegansCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChemicalsClustered Regularly Interspaced Short Palindromic RepeatsCombining SiteCommunitiesCulicidaeCysteineDNA BindingDNA Binding DomainDNA Binding InteractionDNA Molecular BiologyDNA boundDNA-Binding Protein MotifsDanio rerioDataDevelopmentDimensionsDiseaseDisorderDrosophilaDrosophila genusDrosophila melanogasterDrugsEffectivenessElementsEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEndopeptidasesEngineeringExcisionExtirpationFishesFliesGene ExpressionGene Transfer TechniquesGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenerationsGenesGeneticGenetic ModelsGoalsGrowthGrowth and DevelopmentGrowth and Development functionHalf-CystineHealthHumanHuman BiologyIngestionInsectaInsectsInsects InvertebratesIntermediary MetabolismIntervening Protein SequenceInvestigationL-CysteineMedicationMetabolic ProcessesMetabolismMiceMice MammalsModalityModel SystemModelingModern ManMolecular BiologyMosquitoesMurineMusNeurosciencesOrganismParasitesPeptide PeptidohydrolasesPharmaceutical PreparationsPhysiologyPlasmidsPlayPoikilothermsPropertyProtein IntronsProteinsQuinic AcidRNA SplicingReactive SiteRemovalReporterReporter GenesResearchRoleS cerevisiaeS. cerevisiaeSaccharomyces cerevisiaeSplicingSubcellular ProcessSurgical RemovalSystemTechnologyTemperatureTestingTissue GrowthTissuesToxic effectToxicitiesTranscription Factor Proto-OncogeneTranscription factor genesTransgenesisTransgenic OrganismsVector-borne diseaseVector-borne infectious diseaseVector-transmitted diseaseVector-transmitted infectious diseaseVertebrate AnimalsVertebratesVisualizationYeastsZebra DanioZebra FishZebrafishadulthoodagesblood-brain barrier crossingbloodbrain barrier crossingcell typedevelopmentaldietarydrug/agentefficacy testingefficacy validationepigenetic gene silencingepigenetic silencingflyfruit flyfungusgene functiongene manipulationgenetic manipulationgenetically manipulategenetically perturbingestinsightinstrumentinteininterestliving systemmodel organismneuralontogenypermissivenesspoikilothermic vertebratespoikilothermypromoterpromotorresectionsocial rolespatial and temporalspatial temporalspatiotemporaltooltranscription factortransgenicvalidate efficacyvectorvector-borne illnessvectorborne diseasevectorborne illnessvectorborne infectious diseasevertebratayeast protein
Description preview
SUMMARY.
Precise tissue- and temporally- specific manipulation of gene expression has driven mechanistic studies across
many different model organisms. Bimodal expression systems such as the Q-system from N. crassa and the
GAL4-system from S. cerevisiae are key genetic tools for elucidating gene function and cellular properties.
These systems were…
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