grant
A Transposon-based Gene Drive to Combat Antimicrobial Resistance
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AccelerationAddressAdvisory CommitteesAllelesAllelomorphsAminoglycoside resistanceAminoglycoside resistantAnimal ModelAnimal Models and Related StudiesAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsAntimicrobial ResistanceAutomobile DrivingBacteriaBacteria resistanceBacteria resistantBacterial GenesBacterial resistantBar CodesBiologyCRISPR transposonCRISPR-Cas transposonsCRISPR-associated transposonsCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell BodyCellsCessation of lifeClinicalClinical PathologyCollectionCoupledDNADNA Double Strand BreakDataDeathDeoxyribonucleic AcidDevelopmentDevelopment PlansDevelopment and ResearchDoctor of PhilosophyDrug resistanceE coliE. coliEffectivenessEngineeringEnsureEnvironmentEpidemicEscherichia coliEukaryotaEukaryoteEvolutionFrequenciesGI colonizationGene TransferGenerationsGenesGeneticGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic ScreeningGenome engineeringGenomicsGoalsHealthHealth Care CostsHealth CostsHorizontal Gene TransferHospitalsHost FactorHost Factor ProteinHumanImmuneImmunesInfectionIntegration Host FactorsInvestigatorsK-AwardsK-Series Research Career ProgramsLaboratory ResearchLateral Gene TransferLiquid substanceLoveMDR organismMDR pathogenMediatingMedicalMedicineMetabolicMicrobial BiofilmsMicrobiologyMiscellaneous AntibioticMobile Genetic ElementsModelingModern ManModern MedicineModificationMolecularOrganismPathologistPathologyPh.D.PhDPhysiciansPlasmidsPopulationPropertyPublic HealthR & DR&DRecombinant DNA TechnologyResearchResearch Career ProgramResearch PersonnelResearch ResourcesResearchersResidenciesResistanceResistance to antibioticsResistant to antibioticsResourcesRunningScientistSexual ReproductionSystemTask ForcesTrainingTranslatingTransmissionWomanWorkadvisory teamanti-microbial resistantanti-microbial resistant pathogenantibiotic drug resistanceantibiotic resistantantimicrobial resistant pathogenbacterial geneticsbacterial resistancebarcodebiofilmblocking factorcareercareer developmentcombatcostdesigndesigningdevelopmentaldrivingdrug resistantendonucleasefluidgastrointestinal tract colonizationgenetic elementgenetically engineeredgut colonizationhomologous recombinationimprovedin vivoinnovateinnovationinnovativeinsightintestinal colonizationliquidliving systemmodel of animalmouse modelmulti-drug resistant organismmulti-drug resistant pathogenmultidrug resistant organismmultidrug resistant pathogenmultiple drug resistant organismmultiple drug resistant pathogenmurine modelnew approachesnovelnovel approachesnovel strategiesnovel strategyoverexpressoverexpressionpathogenpathogen genomicspreservationprogramsprototyperepairrepairedresearch and developmentresistance against aminoglycosideresistance generesistance locusresistance to Bacteriaresistance to Bacterialresistance to Drugresistance to aminoglycosideresistance to anti-microbialresistantresistant generesistant to Bacteriaresistant to Bacterialresistant to Drugresistant to aminoglycosideresistant to antimicrobialsuccesssynthetic biologytooltransmission processtransposon-associated CRISPR-Casvirtual
Description preview
This proposal outlines a research and career development plan to develop a transposon-based gene
drive to combat antimicrobial resistance (AMR). AMR is an existential threat to modern medicine and global
public health, causing over 2.8 million infections and 35,000 deaths annually in the U.S. alone. E. coli ST131
exemplifies this threat as a…
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