grant
A Systems Epidemiology Approach for Predicting Methotrexate Neurotoxicity in Pediatric Acute Leukemia
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 21 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20250-11 years oldAcuteAcute Lymphoblastic LeukemiaAcute Lymphocytic LeukemiaAcute Lymphoid LeukemiaAcute leukemiaAddressAdolescentAdolescent YouthAffectAlogiaAnepiaAntimetabolitesAphasiaBiologicalBiological MarkersCNS Nervous SystemCausalityCentral Nervous SystemCephalalgiaCephalgiaCephalodyniaCerebrospinal FluidCharacteristicsChildChild YouthChildhoodChildhood ALLChildhood Acute Lymphoblastic LeukemiaChildhood Acute Lymphocytic LeukemiaChildhood Acute Lymphogenous LeukemiaChildhood Acute Lymphoid LeukemiaChildren (0-21)ClinicalClinical DataClinical ManagementComplexCranial PainDWI (diffusion weighted imaging)DWI-MRIDataDecrease disparityDiagnosisDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiseaseDisorderDisparitiesDisparityDistressDoseDose LimitingDysfunctionEncephalopathiesEpidemiologyEthnic GroupEthnic OriginEthnic PeopleEthnic PopulationEthnic individualEthnicityEthnicity PeopleEthnicity PopulationEtiologyFatigueFunctional disorderFutureGene variantGenetic DiversityGenetic VariationGenomicsGenotypeGoalsHead PainHeadacheHereditaryHost FactorHost Factor ProteinIncidenceInferiorInfrastructureInheritedInstitutionIntegration Host FactorsInterventionInvestigationL1 Lymphocytic LeukemiaLack of EnergyLatinoLatino PopulationLatino groupLatino individualLatino peopleLatinosLeukemia Acute Lymphoblastic ChemotherapyLogagnosiaLogamnesiaLogastheniaLower disparityLymphoblastic Leukemia, Acute, L1MR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMethotrexateMethotrexate MethylaminopterinMethotrexatumMetotrexatoMolecularMorbidityMorbidity - disease rateNMR ImagingNMR TomographyNervous System InjuriesNervous System TraumaNervous System damageNeuranatomiesNeuranatomyNeuraxisNeuroanatomiesNeuroanatomyNeurologic ManifestationsNeurologic Signs and SymptomsNeurologic SymptomsNeurological DamageNeurological InjuryNeurological ManifestationsNeurological Signs and SymptomsNeurological traumaNewly DiagnosedNuclear Magnetic Resonance ImagingOutcomePainPainfulParticipantPathway interactionsPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatientsPediatric ALLPediatric Acute Lymphoblastic LeukemiaPediatric Acute Lymphocytic LeukemiaPediatric Acute Lymphogenous LeukemiaPediatric Acute Lymphoid LeukemiaPediatric cohortPharmacogenomicsPharmacometabolomicsPharmacometabonomicsPhenotypePhysiopathologyPrecursor Cell Lymphoblastic LeukemiaPrecursor Lymphoblastic LeukemiaPredictive FactorPreventative strategyPrevention strategyPreventive strategyProcessProspective cohortQOLQTLQuality of lifeQuantitative Trait LociRelapseReportingResearchResearch ResourcesResourcesRiskSamplingScheduleSeizuresSurvival RateSymptomsSystemTechniquesToxic effectToxicitiesTreatment EfficacyTreatment-related toxicityZeugmatographyacute lymphatic leukemiaacute lymphoblastic leukemia Chemotherapyacute lymphogenous leukemiaacute lymphomatic leukemiaallelic variantbio-markersbiologicbiologic markerbiomarkerbiomarker identificationcancer diagnosiscausationcerebral spinal fluidchemotherapychild patientsclinical developmentclinical riskcohortcomparativecurative interventioncurative therapeuticcurative therapycurative treatmentsdMRIdiffusion tensor imagingdisease causationdisparities in treatmentdisparity in ethnicdisparity reductionepidemiologicepidemiologicalethnic based disparityethnic disadvantageethnic disparityethnic diversityethnic inequalityethnic inequityethnic subgroupethnically diverseethnicity disparityethnicity groupevidence baseexperiencegenetic variantgenomic varianthead achehigh riskidentification of biomarkersidentification of new biomarkersimprovedimproved outcomeinequality in treatmentinfant ALLinnovateinnovationinnovativeinsightintervention efficacyjuvenilejuvenile humankidsleukemia relapseleukemia treatmentleukemic therapymarker identificationmetabolism measurementmetabolomicsmetabonomicsmitigate disparitymulti-ethnicmultiethnicmultiomicsmultiple omicsneural imagingneural manifestationneural networkneuro-imagingneuroimagingneuroimaging biomarkerneuroimaging markerneurological imagingneuron toxicityneuronal toxicityneuropathic painneurotoxicityneurotraumanew markernovelnovel biomarkernovel markerpainful neuropathypanomicspathophysiologypathwaypatient stratificationpediatricpediatric acute leukemiapediatric patientspre-clinical toxicitypreclinical toxicitypreventpreventingprospectiverecurrent leukemiareduce disparityreduction in disparityrelapse riskremediationresponserisk stratificationscreeningscreeningsside effectsite targeted deliveryspinal fluidstratified patientstratify risksubstantia albatargeted deliverytherapeutic efficacytherapeutic targettherapeutic toxicitytherapy associated toxicitytherapy efficacytherapy related toxicitytherapy toxicitytractographytranslational opportunitiestranslational potentialtreatment disparitytreatment inequalitytreatment inequitytreatment toxicitytreatment-associated toxicitywhite matteryoungster
Description preview
PROJECT ABSTRACT
Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in childhood. Although survival rates
for childhood ALL have improved in recent decades, ethnic disparities persist. Compared to most other ethnic
groups, Latinos experience both a higher incidence of childhood ALL and poorer survival. The etiology of these…
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