grant
A Selective Serotonin Reuptake Inhibitor for Asthma Patients with Frequent Exacerbations
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025(TNF)-α1, 2-Dehydrocortisone21+ years oldAcuteAdrenal Cortex HormonesAdultAdult HumanAdult asthmaAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAgeAgonistAllergic asthmaAllergyAnimal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntiinflammatory EffectAntimuscarinic AgentsAnxietyAsthmaAsthma in ChildrenAttenuatedB cell differentiation factorB cell growth factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-1B-Cell Differentiation Factor-2B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1B-Cell Stimulatory Factor-2BCDFBCDF-1BCGFBCGF-1BCSF 1BSF-1BSF-2BSF1BSF2BinetrakinBlood EosinophilBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood SerumBlood monocyteBronchial AsthmaBronchoalveolar Lavage FluidCD3CD3 AntigensCD3 ComplexCD3 moleculeCachectinCell BodyCellsChildhood AsthmaCitalopramClinicClinical DataClinical TrialsCo-StimulatorCollaborationsComputerized Medical RecordCorticoidsCorticosteroidsCostimulatorCytalopramDataDeath RateDehydrocortisoneDelta(1)-CortisoneDeltacortisoneDeltadehydrocortisoneDepressed moodDevelopmentDiagnosisDiseaseDisorderDoseElectronic Medical RecordEmotional DepressionEmotionsEndogenous Nitrate VasodilatorEndothelium-Derived Nitric OxideEosinophilic GranulocyteEosinophilic LeukocyteEpidermal Thymocyte Activating FactorEscitalopramExclusionExhalationExhalingExtrinsic asthmaFellowship ProgramFrequenciesFundingGene TranscriptionGenetic TranscriptionGlucocorticoid ReceptorGrantHPGFHealthHepatocyte-Stimulating FactorHigh PrevalenceHispanic PopulationsHispanic groupHispanic individualHispanic peopleHispanicsHistoryHybridoma Growth FactorIFN-beta 2IFNB2IL-2IL-4IL-6IL2 ProteinIL4 ProteinIL6 ProteinImmunologyImpoverishedIn VitroInflammationInhalationInhalingInterleukin 2Interleukin 2 PrecursorInterleukin IIInterleukin-2Interleukin-4Interleukin-4 PrecursorInterleukin-6Interleukine 2Interleukine 2 PrecursorInterleukine IIInvestigatorsLipopolysaccharidesLiteratureLung InflammationLymphatic cellLymphocyteLymphocyte Mitogenic FactorLymphocyte Stimulatory Factor 1LymphocyticMCGF-2MGI-2MacrophageMacrophage-Derived TNFMajor Depressive DisorderMarrow EosinophilMarrow NeutrophilMarrow monocyteMast Cell Growth Factor-2MediatingMediatorMental DepressionMetacortandracinMinorityMitogenic FactorMonocyte-Derived TNFMononitrogen MonoxideMoodsMuscarinic AntagonistsMyeloid Differentiation-Inducing ProteinMφNHLBINIAIDNational Heart, Lung, and Blood InstituteNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthNeutrophilic GranulocyteNeutrophilic LeukocyteNitric OxideNitrogen MonoxideNitrogen ProtoxideOKT3 antigenOralOut-patientsOutcomeOutcome MeasureOutpatientsPatientsPediatric asthmaPersonsPhasePlacebosPlasmacytoma Growth FactorPneumonitisPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPovertyPrediction of Response to TherapyPrednisonePrednisonumPrevalenceProcessPropertyPsyche structurePublic HealthPulmonary InflammationQOLQuality of lifeQuestionnairesRNA ExpressionRandomizedRecording of previous eventsReportingResearch PersonnelResearchersRespiratory ExpirationSF-36SSRISSRIsSamplingSecondary toSelective Serotonin Reuptake InhibitorSelective serotonin re-uptake inhibitorSerumSeveritiesSham TreatmentSiteStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationSteroid CompoundSteroidsT cell growth factorT-Cell Growth FactorT-Cell Growth Factor 2T-Cell Stimulating FactorT3 AntigensT3 ComplexT3 moleculeTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestingTexasThymocyte Stimulating FactorTranscriptionTumor Necrosis FactorTumor Necrosis Factor-alphaUnited States National Institutes of HealthWomanadulthoodagesanti-depressant agentanti-depressant drugsanti-depressantsanti-depressive agentsanti-inflammatory effectanxiety symptomsanxious symptomasthma attackasthma exacerbationasthma patientasthmatic patientatopic asthmaattenuateattenuatesclinical depressiondelta-Cortisonedepresseddepressiondepression symptomdepressivedepressive symptomsdevelopmentaldouble-blind placebo control trialdouble-blind placebo controlled trialdouble-masked controlled trialeffective therapyeffective treatmentendothelial cell derived relaxing factoreosinophilexacerbation in asthmaexacerbation prone asthmaexacerbation prone asthmaticexperienceextrinsic allergic asthmahistoriesimprovedinner cityinterferon beta 2lymph cellmajor depressionmajor depression disordermeasurable outcomemenmentalmodel of animalmonocytemortality ratemortality rationegative emotional stateneutrophiloutcome measurementpredict responsivenesspredict therapeutic responsepredict therapy responsepredicting responseprimary outcomeprofessorprogramspsychologicpsychologicalrandomisationrandomizationrandomized placebo control trialrandomized placebo controlled trialrandomly assignedresponsesadnessserotonin reuptake inhibitorsexsham therapystatistical analysissubclinical depressiontherapy predictiontreatment grouptreatment predictiontreatment response prediction
Description preview
Project Summary/Abstract
Asthma prevalence has increased in recent years with 8.4% of adults diagnosed with asthma. Asthma can be
a lifelong disease. These rates increase with age, are 60% higher in women than men and are especially high
in African Americans. Thus, adult asthma is a major health concern. Rates of uncontrolled asthma also
increase…
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